| SP | Santana, J.Santana, Johan | 2001-10 Twins | L | 183.0 | 39 | 39 | 24 | 7 | 3.38 | .274 | 1.10 | 7.2 | 2.7 | 8.4 | 279.2 | 224 | 113 | 105 | 27 | 85 | 260 | 6 | 0 | 0 | 0 | 30 | 8 | 11 | 3.39 |
| SP | Johnson, R.Johnson, Randy † | 1995-03 M's | L | 175.0 | 37 | 37 | 19 | 8 | 2.82 | .280 | 1.15 | 7.0 | 3.4 | 8.6 | 274.0 | 212 | 90 | 86 | 26 | 104 | 261 | 7 | 0 | 0 | 2 | 27 | 4 | 7 | 3.51 |
| CL | Hernandez, R.Hernandez, Roberto | 1981-96 ChiSox | R | 164.5 | 69 | 0 | 8 | 9 | 3.05 | .312 | 1.33 | 8.5 | 3.6 | 6.4 | 73.2 | 69 | 29 | 25 | 7 | 29 | 52 | 0 | 51 | 4 | 0 | 0 | 2 | 2 | 4.10 |
| SP | Kluber, C.Kluber, Corey † | 2007-19 Indians | R | 162.0 | 35 | 35 | 17 | 9 | 2.60 | .268 | 1.07 | 7.3 | 2.4 | 8.9 | 259.2 | 211 | 79 | 75 | 21 | 68 | 256 | 6 | 0 | 0 | 0 | 27 | 6 | 5 | 2.93 |
| CL | Benitez, A.Benitez, Armando † | 1992-97 Orioles | R | 153.5 | 68 | 0 | 9 | 7 | 2.59 | .234 | 0.90 | 4.7 | 3.5 | 10.2 | 73.0 | 38 | 21 | 21 | 9 | 28 | 83 | 0 | 41 | 5 | 0 | 0 | 1 | 1 | 3.52 |
| CL | Doolittle, S.Doolittle, Sean † | 2012-19 A's | L | 142.5 | 62 | 0 | 8 | 7 | 2.48 | .237 | 0.92 | 6.9 | 1.4 | 9.3 | 65.1 | 50 | 22 | 18 | 4 | 10 | 67 | 0 | 39 | 4 | 0 | 0 | 1 | 0 | 2.25 |
| SP | Verlander, J.Verlander, Justin † | 2006-14 Tigers | R | 140.0 | 33 | 33 | 19 | 6 | 3.50 | .292 | 1.22 | 8.3 | 2.7 | 6.3 | 234.1 | 215 | 96 | 91 | 24 | 71 | 164 | 4 | 0 | 0 | 1 | 24 | 4 | 6 | 3.89 |
| CL | Sasaki, K.Sasaki, Kazuhiro | 1995-03 M's | R | 126.0 | 71 | 0 | 4 | 9 | 4.67 | .344 | 1.56 | 10.8 | 3.3 | 5.8 | 71.1 | 85 | 38 | 37 | 9 | 26 | 46 | 0 | 50 | 6 | 0 | 0 | 1 | 2 | 4.49 |