| SP | Reulbach, E.Reulbach, Ed † | Hissing Toads | R | 114.0 | 23 | 23 | 16 | 1 | 2.91 | .282 | 1.17 | 6.3 | 4.3 | 3.7 | 139.0 | 97 | 46 | 45 | 13 | 66 | 57 | 0 | 0 | 0 | 0 | 17 | 1 | 1 | 4.84 |
| SP | deGrom, J.deGrom, Jacob † | Hissing Toads | R | 109.0 | 24 | 24 | 13 | 7 | 2.60 | .257 | 1.03 | 7.2 | 2.1 | 11.0 | 159.0 | 127 | 47 | 46 | 13 | 37 | 195 | 0 | 0 | 0 | 0 | 18 | 1 | 0 | 2.33 |
| SP | Johnson, R.Johnson, Randy † # | Warriors | L | 103.0 | 23 | 23 | 13 | 3 | 3.44 | .292 | 1.23 | 8.5 | 2.6 | 7.1 | 164.2 | 154 | 66 | 63 | 15 | 48 | 130 | 5 | 0 | 0 | 1 | 13 | 2 | 1 | 3.52 |
| CL | Doolittle, S.Doolittle, Sean † | INQUISITORS | L | 88.0 | 62 | 0 | 3 | 6 | 4.09 | .312 | 1.32 | 8.8 | 3.3 | 9.5 | 72.2 | 70 | 35 | 33 | 6 | 26 | 76 | 0 | 30 | 3 | 0 | 0 | 3 | 0 | 3.18 |
| SP | Martinez, P.Martinez, Pedro † $ | Astros | R | 82.0 | 24 | 24 | 11 | 8 | 3.57 | .305 | 1.30 | 8.3 | 3.4 | 8.7 | 174.0 | 160 | 85 | 69 | 20 | 66 | 168 | 2 | 0 | 0 | 0 | 17 | 3 | 6 | 3.75 |
| SP | Arrieta, J.Arrieta, Jake $ | Bombers | R | 78.0 | 24 | 24 | 11 | 6 | 3.38 | .300 | 1.26 | 8.0 | 3.3 | 7.3 | 144.0 | 128 | 60 | 54 | 11 | 53 | 117 | 0 | 0 | 0 | 0 | 14 | 4 | 4 | 3.56 |
| CL | Wagner, B.Wagner, Billy † | Astros | L | 76.5 | 48 | 0 | 1 | 7 | 4.31 | .379 | 1.83 | 9.2 | 7.3 | 9.8 | 48.0 | 49 | 25 | 23 | 2 | 39 | 52 | 0 | 33 | 4 | 0 | 0 | 0 | 0 | 3.81 |