| SP | Scherzer, M.Scherzer, Max † | Diamondbacks | R | 240.0 | 40 | 40 | 26 | 12 | 2.40 | .251 | 0.97 | 6.7 | 2.1 | 10.4 | 307.2 | 227 | 90 | 82 | 26 | 70 | 355 | 11 | 0 | 0 | 6 | 29 | 13 | 5 | 2.60 |
| SP | Wesneski, H.Wesneski, Hayden † | Cubs | R | 193.0 | 40 | 40 | 24 | 8 | 2.68 | .255 | 1.00 | 7.1 | 1.9 | 9.2 | 262.1 | 208 | 80 | 78 | 17 | 55 | 269 | 0 | 0 | 0 | 0 | 32 | 7 | 0 | 2.50 |
| CL | Hughes, B.Hughes, Brandon † | Cubs | L | 165.5 | 77 | 0 | 8 | 5 | 3.28 | .276 | 1.03 | 6.7 | 2.6 | 10.9 | 79.2 | 59 | 30 | 29 | 13 | 23 | 96 | 0 | 47 | 4 | 0 | 0 | 9 | 3 | 3.92 |
| SP | Alcantara, S.Alcantara, Sandy † | Marlins | R | 156.0 | 37 | 37 | 17 | 13 | 2.79 | .276 | 1.12 | 7.5 | 2.6 | 9.3 | 274.0 | 228 | 88 | 85 | 26 | 78 | 282 | 6 | 0 | 0 | 1 | 29 | 7 | 4 | 3.11 |
| SP | deGrom, J.deGrom, Jacob † | Mets | R | 147.0 | 36 | 36 | 18 | 8 | 2.99 | .284 | 1.16 | 8.4 | 2.0 | 10.6 | 232.0 | 217 | 80 | 77 | 27 | 51 | 273 | 0 | 0 | 0 | 0 | 23 | 8 | 0 | 2.92 |
| CL | Ottavino, A.Ottavino, Adam † | Pirates | R | 134.5 | 63 | 0 | 0 | 1 | 3.19 | .276 | 1.11 | 7.3 | 2.8 | 10.5 | 62.0 | 50 | 23 | 22 | 7 | 19 | 72 | 0 | 49 | 4 | 0 | 0 | 2 | 6 | 3.16 |