| SP | Martinez, P.Martinez, Pedro # | Blue Fish | R | 168.0 | 34 | 34 | 18 | 6 | 2.94 | .246 | 0.97 | 6.9 | 1.8 | 7.8 | 260.0 | 200 | 86 | 85 | 25 | 51 | 226 | 8 | 0 | 0 | 5 | 21 | 3 | 2 | 3.13 |
| SP | deGrom, J.deGrom, Jacob † $$ | Warriors | R | 159.0 | 35 | 35 | 16 | 7 | 2.54 | .243 | 0.94 | 6.0 | 2.5 | 9.0 | 255.0 | 169 | 74 | 72 | 31 | 71 | 256 | 2 | 0 | 0 | 1 | 27 | 5 | 0 | 3.47 |
| CL | Feliz, N.Feliz, Neftali † | Astros | R | 145.5 | 73 | 0 | 7 | 6 | 3.64 | .302 | 1.29 | 7.2 | 4.4 | 9.3 | 84.0 | 67 | 34 | 34 | 10 | 41 | 87 | 0 | 43 | 4 | 0 | 0 | 1 | 0 | 3.98 |
| SP | Koufax, S.Koufax, Sandy † | Bulldogs | L | 145.0 | 35 | 35 | 18 | 10 | 3.19 | .296 | 1.24 | 7.7 | 3.4 | 8.1 | 259.2 | 223 | 96 | 92 | 18 | 99 | 232 | 5 | 0 | 0 | 0 | 26 | 5 | 8 | 3.32 |
| CL | Jansen, K.Jansen, Kenley † | Bulldogs | R | 143.0 | 70 | 0 | 5 | 4 | 2.63 | .294 | 1.24 | 7.3 | 3.9 | 8.1 | 72.0 | 58 | 21 | 21 | 5 | 31 | 65 | 0 | 42 | 3 | 0 | 0 | 1 | 1 | 3.43 |
| SP | Johnson, W.Johnson, Walter | Mets | R | 128.0 | 37 | 37 | 14 | 12 | 2.91 | .274 | 1.10 | 8.3 | 1.6 | 4.5 | 266.0 | 245 | 97 | 86 | 22 | 48 | 134 | 8 | 0 | 0 | 2 | 25 | 8 | 7 | 3.70 |