| SP | Martinez, P.Martinez, Pedro † | Snakes | R | 130.0 | 28 | 28 | 14 | 11 | 2.97 | .285 | 1.16 | 8.1 | 2.4 | 10.0 | 221.1 | 198 | 82 | 73 | 24 | 59 | 246 | 10 | 0 | 0 | 3 | 20 | 8 | 3 | 3.10 |
| SP | Lincecum, T.Lincecum, Tim # | Demons | R | 113.0 | 28 | 28 | 14 | 8 | 3.17 | .280 | 1.15 | 7.6 | 2.8 | 8.7 | 187.2 | 157 | 66 | 66 | 20 | 59 | 181 | 6 | 0 | 0 | 1 | 19 | 3 | 6 | 3.45 |
| SP | Santana, J.Santana, Johan † | Otters | L | 107.0 | 29 | 29 | 14 | 9 | 3.19 | .285 | 1.19 | 8.3 | 2.4 | 8.5 | 192.0 | 178 | 74 | 68 | 18 | 51 | 182 | 2 | 0 | 0 | 0 | 19 | 1 | 2 | 3.14 |
| SP | Shields, J.Shields, James † | Red Bears | R | 97.0 | 27 | 27 | 14 | 7 | 3.52 | .305 | 1.28 | 8.9 | 2.6 | 7.2 | 176.1 | 175 | 70 | 69 | 22 | 50 | 140 | 2 | 0 | 0 | 0 | 17 | 7 | 5 | 4.01 |
| RP | Soriano, R.Soriano, Rafael | Red Bears | R | 97.0 | 71 | 0 | 11 | 3 | 2.04 | .263 | 1.03 | 6.7 | 2.7 | 9.2 | 105.2 | 78 | 26 | 24 | 7 | 31 | 107 | 0 | 4 | 4 | 0 | 0 | 4 | 0 | 2.83 |
| SP | Duchscherer, J.Duchscherer, Justin | Demons | R | 96.0 | 28 | 28 | 12 | 3 | 3.30 | .280 | 1.15 | 7.6 | 2.8 | 6.3 | 174.1 | 147 | 70 | 64 | 21 | 54 | 121 | 0 | 0 | 0 | 0 | 17 | 2 | 4 | 4.14 |
| SP | Vazquez, J.Vazquez, Javier # | Tide | R | 88.0 | 26 | 26 | 14 | 6 | 3.97 | .300 | 1.25 | 9.0 | 2.3 | 8.3 | 167.2 | 167 | 79 | 74 | 24 | 43 | 154 | 0 | 0 | 0 | 0 | 18 | 6 | 3 | 3.90 |