| SP | Koufax, S.Koufax, Sandy † # | Frogs | L | 139.0 | 32 | 32 | 18 | 9 | 3.51 | .284 | 1.16 | 7.6 | 2.8 | 8.0 | 241.0 | 204 | 102 | 94 | 24 | 75 | 214 | 9 | 0 | 0 | 2 | 20 | 8 | 6 | 3.55 |
| SP | Verlander, J.Verlander, Justin # | Reapers | R | 131.0 | 32 | 32 | 14 | 9 | 2.78 | .257 | 1.02 | 6.8 | 2.4 | 8.8 | 233.1 | 176 | 72 | 72 | 23 | 62 | 229 | 2 | 0 | 0 | 1 | 25 | 4 | 8 | 3.17 |
| SP | Kershaw, C.Kershaw, Clayton † # | Devils | L | 119.0 | 32 | 32 | 15 | 13 | 3.46 | .266 | 1.06 | 7.8 | 1.7 | 8.7 | 242.0 | 210 | 95 | 93 | 26 | 46 | 235 | 8 | 0 | 0 | 2 | 20 | 7 | 6 | 3.11 |
| CL | Feliz, N.Feliz, Neftali † | Bulls | R | 118.0 | 69 | 0 | 6 | 10 | 3.12 | .292 | 1.23 | 6.7 | 4.3 | 6.4 | 75.0 | 56 | 27 | 26 | 8 | 36 | 53 | 0 | 38 | 6 | 0 | 0 | 1 | 0 | 4.45 |
| SP | Greinke, Z.Greinke, Zack † | Baseball Club | R | 108.0 | 31 | 31 | 15 | 10 | 3.29 | .284 | 1.15 | 7.5 | 2.8 | 5.4 | 200.0 | 167 | 75 | 73 | 18 | 63 | 121 | 4 | 0 | 0 | 1 | 18 | 8 | 3 | 4.03 |
| SP | Scherzer, M.Scherzer, Max | Cougars | R | 102.0 | 32 | 32 | 13 | 10 | 3.54 | .277 | 1.14 | 6.7 | 3.6 | 8.4 | 216.0 | 161 | 91 | 85 | 19 | 86 | 201 | 4 | 0 | 0 | 2 | 22 | 1 | 7 | 3.49 |
| SP | Alexander, P.Alexander, Pete | Bulls | R | 101.0 | 31 | 31 | 12 | 9 | 3.06 | .271 | 1.10 | 7.3 | 2.6 | 5.2 | 223.2 | 181 | 85 | 76 | 15 | 65 | 128 | 2 | 0 | 0 | 0 | 22 | 3 | 3 | 3.64 |