| SP | Koufax, S.Koufax, Sandy † | Classics | L | 237.0 | 36 | 36 | 23 | 9 | 2.15 | .242 | 0.94 | 6.0 | 2.5 | 7.1 | 301.1 | 199 | 77 | 72 | 25 | 83 | 236 | 21 | 0 | 0 | 5 | 30 | 6 | 4 | 3.40 |
| SP | Martinez, P.Martinez, Pedro † $$ | Bees | R | 173.0 | 36 | 36 | 17 | 9 | 2.69 | .256 | 1.01 | 6.6 | 2.6 | 8.4 | 264.2 | 193 | 83 | 79 | 21 | 75 | 246 | 14 | 0 | 0 | 5 | 25 | 5 | 7 | 3.08 |
| SP | Leonard, D.Leonard, Dutch $ | Industriales | L | 157.0 | 35 | 35 | 17 | 10 | 2.21 | .248 | 0.98 | 6.1 | 2.7 | 4.3 | 252.0 | 172 | 66 | 62 | 16 | 75 | 121 | 3 | 0 | 0 | 1 | 29 | 2 | 2 | 3.78 |
| SP | Alexander, P.Alexander, Pete | Classics | R | 154.0 | 32 | 32 | 15 | 11 | 2.73 | .243 | 0.94 | 6.6 | 1.9 | 4.9 | 273.2 | 199 | 85 | 83 | 23 | 58 | 149 | 19 | 0 | 0 | 2 | 23 | 7 | 3 | 3.72 |
| SP | Arrieta, J.Arrieta, Jake † # | Bees | R | 152.0 | 35 | 35 | 18 | 6 | 3.13 | .280 | 1.15 | 7.2 | 3.1 | 8.1 | 233.0 | 187 | 85 | 81 | 16 | 80 | 209 | 5 | 0 | 0 | 4 | 22 | 5 | 3 | 3.19 |
| CL | Jansen, K.Jansen, Kenley † | A's | R | 134.5 | 70 | 0 | 5 | 7 | 3.44 | .287 | 1.18 | 7.8 | 2.8 | 9.1 | 68.0 | 59 | 28 | 26 | 5 | 21 | 69 | 0 | 45 | 5 | 0 | 0 | 2 | 1 | 2.94 |
| CL | Feliz, N.Feliz, Neftali † | Devils | R | 132.0 | 96 | 0 | 5 | 7 | 3.71 | .259 | 1.05 | 6.3 | 3.2 | 8.2 | 102.0 | 71 | 42 | 42 | 13 | 36 | 93 | 0 | 42 | 5 | 0 | 0 | 0 | 0 | 3.89 |