| SP | Koufax, S.Koufax, Sandy † | Classics | L | 160.0 | 28 | 28 | 17 | 9 | 2.74 | .261 | 1.05 | 6.7 | 2.7 | 8.3 | 227.0 | 170 | 75 | 69 | 17 | 68 | 209 | 16 | 0 | 0 | 3 | 20 | 3 | 4 | 3.07 |
| CL | Wagner, B.Wagner, Billy † | Rubs It | L | 126.5 | 65 | 0 | 6 | 5 | 3.17 | .263 | 1.07 | 6.5 | 3.2 | 10.3 | 71.0 | 51 | 25 | 25 | 8 | 25 | 81 | 0 | 37 | 6 | 0 | 0 | 0 | 1 | 3.24 |
| SP | McLain, D.McLain, Denny # | Lions | R | 120.0 | 27 | 27 | 13 | 9 | 3.14 | .264 | 1.07 | 7.5 | 2.1 | 5.0 | 221.0 | 184 | 81 | 77 | 18 | 52 | 122 | 15 | 0 | 0 | 3 | 17 | 2 | 2 | 3.69 |
| SP | Reulbach, E.Reulbach, Ed † $$ | Blue Sox | R | 114.0 | 28 | 27 | 15 | 5 | 2.97 | .298 | 1.25 | 7.2 | 4.1 | 3.8 | 185.0 | 147 | 66 | 61 | 17 | 85 | 78 | 2 | 0 | 0 | 0 | 19 | 4 | 2 | 4.79 |
| SP | Leonard, D.Leonard, Dutch $ | Classics | L | 114.0 | 27 | 27 | 12 | 6 | 2.51 | .244 | 0.96 | 6.2 | 2.4 | 5.3 | 197.1 | 136 | 60 | 55 | 15 | 53 | 117 | 2 | 0 | 0 | 1 | 22 | 2 | 2 | 3.64 |
| SP | deGrom, J.deGrom, Jacob † $ | Fence Busters | R | 107.0 | 28 | 28 | 13 | 6 | 3.01 | .270 | 1.09 | 7.4 | 2.4 | 8.6 | 185.1 | 153 | 67 | 62 | 21 | 49 | 177 | 0 | 0 | 0 | 0 | 20 | 4 | 0 | 3.42 |