| SP | deGrom, J.deGrom, Jacob † # | Reapers | R | 115.0 | 22 | 22 | 11 | 7 | 2.07 | .252 | 0.99 | 6.7 | 2.3 | 10.7 | 161.0 | 119 | 38 | 37 | 13 | 41 | 192 | 3 | 0 | 0 | 3 | 18 | 3 | 2 | 2.48 |
| SP | Hernandez, F.Hernandez, Felix † | Demons | R | 109.0 | 22 | 22 | 14 | 6 | 3.20 | .292 | 1.22 | 7.3 | 3.8 | 9.7 | 163.1 | 132 | 60 | 58 | 13 | 68 | 175 | 3 | 0 | 0 | 2 | 13 | 2 | 5 | 3.18 |
| SP | Kluber, C.Kluber, Corey † # | Eagles | R | 87.0 | 23 | 23 | 10 | 10 | 3.07 | .276 | 1.14 | 8.4 | 1.9 | 10.5 | 173.0 | 161 | 63 | 59 | 19 | 36 | 202 | 4 | 0 | 0 | 0 | 16 | 1 | 0 | 2.73 |
| SP | Greinke, Z.Greinke, Zack # | Crabs | R | 86.0 | 20 | 20 | 11 | 5 | 3.50 | .251 | 0.97 | 7.1 | 1.6 | 7.7 | 154.1 | 121 | 62 | 60 | 21 | 28 | 132 | 4 | 0 | 0 | 1 | 12 | 6 | 0 | 3.72 |
| SP | Darvish, Y.Darvish, Yu † # | Dukes | R | 84.0 | 21 | 21 | 12 | 3 | 3.77 | .279 | 1.13 | 6.9 | 3.3 | 10.4 | 129.0 | 99 | 55 | 54 | 15 | 47 | 149 | 1 | 0 | 0 | 0 | 12 | 4 | 3 | 3.39 |
| CL | Jansen, K.Jansen, Kenley † | Mets | R | 78.5 | 54 | 0 | 1 | 3 | 2.60 | .262 | 1.05 | 7.2 | 2.4 | 10.1 | 65.2 | 52 | 20 | 19 | 5 | 17 | 73 | 0 | 23 | 1 | 0 | 0 | 1 | 2 | 2.58 |