| SP | Duchscherer, J.Duchscherer, Justin † | Bees | R | 92.0 | 22 | 22 | 11 | 7 | 2.91 | .245 | 0.97 | 6.7 | 2.0 | 6.2 | 163.2 | 122 | 55 | 53 | 13 | 36 | 113 | 3 | 0 | 0 | 2 | 15 | 1 | 3 | 3.33 |
| SP | Halladay, R.Halladay, Roy † | Monarchs | R | 87.0 | 22 | 22 | 11 | 8 | 3.16 | .270 | 1.08 | 7.6 | 2.2 | 5.2 | 159.2 | 135 | 64 | 56 | 14 | 38 | 92 | 8 | 0 | 0 | 1 | 16 | 4 | 3 | 3.78 |
| SP | Santana, J.Santana, Johan † | Bucs | L | 84.0 | 23 | 23 | 12 | 7 | 3.78 | .283 | 1.16 | 7.6 | 2.8 | 8.0 | 152.1 | 129 | 67 | 64 | 21 | 47 | 135 | 4 | 0 | 0 | 3 | 11 | 4 | 8 | 4.03 |
| SP | Lincecum, T.Lincecum, Tim † | Wolves | R | 83.0 | 23 | 23 | 12 | 8 | 3.71 | .323 | 1.41 | 9.5 | 3.2 | 10.4 | 153.0 | 161 | 65 | 63 | 17 | 54 | 177 | 2 | 0 | 0 | 1 | 14 | 4 | 4 | 3.27 |
| SP | Johnson, R.Johnson, Randy † | Gorillas | L | 82.0 | 23 | 23 | 12 | 7 | 3.91 | .309 | 1.31 | 8.7 | 3.2 | 10.1 | 158.2 | 152 | 72 | 69 | 18 | 56 | 178 | 4 | 0 | 0 | 0 | 14 | 5 | 2 | 3.39 |
| SP | Schilling, C.Schilling, Curt # | Spiders | R | 76.0 | 23 | 23 | 8 | 12 | 2.97 | .265 | 1.06 | 7.8 | 1.8 | 9.4 | 173.0 | 149 | 61 | 57 | 15 | 34 | 180 | 5 | 0 | 0 | 1 | 17 | 4 | 0 | 2.71 |
| CL | Balfour, G.Balfour, Grant † | Old Foes | R | 75.0 | 48 | 0 | 1 | 2 | 2.35 | .241 | 0.89 | 4.8 | 3.4 | 10.2 | 53.2 | 28 | 14 | 14 | 3 | 20 | 60 | 0 | 22 | 1 | 0 | 0 | 3 | 2 | 2.77 |