| SP | Santana, J.Santana, Johan † | Pigs | L | 105.0 | 21 | 21 | 13 | 4 | 2.95 | .284 | 1.16 | 7.9 | 2.5 | 10.1 | 152.1 | 134 | 52 | 50 | 18 | 43 | 171 | 0 | 0 | 0 | 0 | 15 | 4 | 3 | 3.22 |
| SP | Sheets, B.Sheets, Ben † # | Miners | R | 91.0 | 21 | 21 | 12 | 2 | 3.63 | .271 | 1.09 | 8.7 | 1.2 | 9.1 | 148.2 | 143 | 61 | 60 | 21 | 19 | 149 | 1 | 0 | 0 | 0 | 14 | 4 | 3 | 3.30 |
| SP | Martinez, P.Martinez, Pedro $ | Red Sox | R | 77.0 | 21 | 21 | 11 | 7 | 3.79 | .301 | 1.23 | 8.1 | 3.0 | 11.3 | 135.1 | 121 | 60 | 57 | 21 | 45 | 169 | 4 | 0 | 0 | 0 | 12 | 9 | 3 | 3.72 |
| SP | Halladay, R.Halladay, Roy | Sluggers | R | 77.0 | 20 | 20 | 10 | 5 | 3.57 | .292 | 1.22 | 9.1 | 1.9 | 7.0 | 146.1 | 147 | 60 | 58 | 21 | 31 | 113 | 4 | 0 | 0 | 1 | 13 | 3 | 0 | 4.02 |
| SP | Schilling, C.Schilling, Curt | Warriors | R | 76.0 | 21 | 21 | 11 | 8 | 3.90 | .295 | 1.22 | 9.1 | 1.9 | 10.6 | 150.0 | 151 | 66 | 65 | 22 | 32 | 177 | 4 | 0 | 0 | 1 | 13 | 5 | 2 | 3.29 |
| SP | Clemens, R.Clemens, Roger † | Mustangs | R | 72.0 | 21 | 21 | 10 | 5 | 3.48 | .264 | 1.04 | 7.1 | 2.3 | 7.2 | 142.1 | 112 | 57 | 55 | 19 | 36 | 114 | 0 | 0 | 0 | 0 | 15 | 5 | 2 | 4.00 |