| SP | Jimenez, U.Jimenez, Ubaldo † | Rockies | R | 153.0 | 37 | 37 | 21 | 8 | 3.55 | .298 | 1.27 | 7.5 | 3.9 | 6.5 | 251.1 | 208 | 100 | 99 | 20 | 110 | 182 | 5 | 0 | 0 | 4 | 23 | 2 | 10 | 3.92 |
| SP | Hernandez, F.Hernandez, Felix † | Monarchs | R | 146.0 | 33 | 33 | 20 | 10 | 3.35 | .268 | 1.09 | 7.6 | 2.3 | 8.1 | 244.1 | 205 | 94 | 91 | 20 | 61 | 220 | 3 | 0 | 0 | 1 | 23 | 3 | 10 | 3.05 |
| SP | Richard, J.Richard, J.R. † | Asses | R | 143.0 | 34 | 33 | 17 | 8 | 2.90 | .282 | 1.16 | 6.7 | 3.8 | 9.6 | 223.2 | 165 | 72 | 72 | 9 | 95 | 238 | 2 | 0 | 0 | 2 | 23 | 4 | 3 | 2.72 |
| CL | Soriano, R.Soriano, Rafael † | Monarchs | R | 135.0 | 69 | 0 | 5 | 5 | 2.95 | .281 | 1.12 | 6.8 | 3.3 | 8.9 | 73.1 | 55 | 25 | 24 | 5 | 27 | 72 | 0 | 42 | 7 | 0 | 0 | 4 | 0 | 3.19 |
| CL | Sanchez, A.Sanchez, Aaron † | B18e Jays | R | 130.5 | 69 | 0 | 0 | 2 | 2.58 | .261 | 1.05 | 5.3 | 4.2 | 5.3 | 69.2 | 41 | 20 | 20 | 4 | 32 | 41 | 0 | 47 | 4 | 0 | 0 | 1 | 4 | 4.00 |
| SP | Verlander, J.Verlander, Justin | Asses | R | 126.0 | 36 | 36 | 14 | 10 | 2.99 | .264 | 1.06 | 6.8 | 2.7 | 8.6 | 241.0 | 183 | 83 | 80 | 18 | 72 | 229 | 3 | 0 | 0 | 1 | 25 | 5 | 2 | 3.03 |
| SP | Cortes Jr., N.Cortes Jr., Nestor † | Yankees | L | 125.0 | 35 | 35 | 19 | 5 | 3.95 | .304 | 1.28 | 8.2 | 3.2 | 9.1 | 203.0 | 186 | 96 | 89 | 21 | 73 | 206 | 0 | 0 | 0 | 0 | 16 | 7 | 6 | 3.50 |
| SP | Gilbert, L.Gilbert, Logan | Monarchs | R | 125.0 | 35 | 35 | 18 | 11 | 3.47 | .270 | 1.08 | 7.1 | 2.6 | 7.6 | 238.1 | 188 | 93 | 92 | 28 | 69 | 202 | 1 | 0 | 0 | 0 | 20 | 7 | 7 | 3.79 |