| SP | Leonard, D.Leonard, Dutch † | Classics | L | 83.0 | 17 | 17 | 11 | 1 | 3.20 | .278 | 1.14 | 6.6 | 3.7 | 5.3 | 118.0 | 86 | 46 | 42 | 12 | 48 | 70 | 1 | 0 | 0 | 1 | 11 | 2 | 2 | 4.41 |
| CL | Jansen, K.Jansen, Kenley † | PRICE SISTERS | R | 72.0 | 45 | 0 | 3 | 4 | 3.27 | .298 | 1.23 | 7.4 | 3.7 | 9.8 | 44.0 | 36 | 17 | 16 | 3 | 18 | 48 | 0 | 22 | 2 | 0 | 0 | 2 | 1 | 3.07 |
| SP | Koufax, S.Koufax, Sandy # | Lions | L | 68.0 | 18 | 18 | 8 | 6 | 3.60 | .279 | 1.15 | 7.6 | 2.8 | 7.8 | 147.1 | 124 | 63 | 59 | 15 | 45 | 127 | 7 | 0 | 0 | 1 | 12 | 2 | 2 | 3.56 |
| SP | deGrom, J.deGrom, Jacob † | PRICE SISTERS | R | 67.0 | 18 | 18 | 10 | 3 | 3.76 | .296 | 1.25 | 8.4 | 2.9 | 9.8 | 107.2 | 100 | 46 | 45 | 16 | 35 | 116 | 0 | 0 | 0 | 0 | 12 | 1 | 0 | 3.79 |
| SP | Fernandez, J.Fernandez, Jose † # | Dark Blues | R | 64.0 | 16 | 16 | 9 | 6 | 3.11 | .269 | 1.09 | 6.9 | 2.9 | 7.4 | 113.0 | 87 | 40 | 39 | 9 | 36 | 93 | 1 | 0 | 0 | 0 | 12 | 2 | 4 | 3.40 |
| SP | Arrieta, J.Arrieta, Jake † # | Dark Blues | R | 64.0 | 18 | 18 | 9 | 1 | 3.80 | .309 | 1.33 | 9.3 | 2.6 | 7.3 | 109.0 | 113 | 46 | 46 | 7 | 32 | 88 | 0 | 0 | 0 | 0 | 12 | 1 | 1 | 3.13 |
| SP | Alexander, P.Alexander, Pete | Brahs | R | 62.0 | 16 | 16 | 7 | 6 | 3.08 | .286 | 1.18 | 8.1 | 2.6 | 4.5 | 119.2 | 107 | 44 | 41 | 10 | 34 | 60 | 8 | 0 | 0 | 1 | 10 | 3 | 0 | 4.02 |
| SP | Verlander, J.Verlander, Justin † | Suns | R | 61.0 | 18 | 18 | 8 | 5 | 3.73 | .308 | 1.32 | 8.6 | 3.3 | 7.5 | 128.0 | 122 | 58 | 53 | 8 | 47 | 106 | 4 | 0 | 0 | 1 | 11 | 2 | 1 | 3.30 |
| SP | Kershaw, C.Kershaw, Clayton | Classics | L | 60.0 | 18 | 18 | 9 | 7 | 3.90 | .266 | 1.08 | 8.3 | 1.4 | 8.9 | 131.2 | 121 | 63 | 57 | 20 | 21 | 130 | 4 | 0 | 0 | 0 | 11 | 1 | 4 | 3.50 |