| SP | deGrom, J.deGrom, Jacob † | Frogs | R | 106.0 | 25 | 25 | 15 | 6 | 3.79 | .300 | 1.27 | 9.1 | 2.4 | 10.6 | 178.0 | 179 | 77 | 75 | 24 | 47 | 209 | 2 | 0 | 0 | 1 | 14 | 3 | 1 | 3.25 |
| SP | Richards, G.Richards, Garrett | Beach Bums | R | 106.0 | 25 | 25 | 14 | 3 | 3.59 | .283 | 1.14 | 7.4 | 2.9 | 8.9 | 170.1 | 140 | 70 | 68 | 19 | 55 | 169 | 1 | 0 | 0 | 1 | 16 | 7 | 14 | 3.56 |
| SP | Fernandez, J.Fernandez, Jose | Brawlers | R | 101.0 | 26 | 26 | 15 | 8 | 3.42 | .286 | 1.18 | 6.7 | 4.0 | 8.4 | 166.0 | 123 | 67 | 63 | 13 | 73 | 155 | 1 | 0 | 0 | 0 | 15 | 3 | 4 | 3.52 |
| SP | Keuchel, D.Keuchel, Dallas | Frogs | L | 101.0 | 25 | 25 | 14 | 7 | 3.65 | .290 | 1.20 | 8.4 | 2.4 | 7.7 | 189.2 | 177 | 78 | 77 | 27 | 50 | 162 | 4 | 0 | 0 | 0 | 15 | 5 | 4 | 4.02 |
| CL | Britton, Z.Britton, Zach † | Westerners | L | 100.0 | 55 | 0 | 5 | 5 | 2.78 | .297 | 1.27 | 7.6 | 3.9 | 8.5 | 58.1 | 49 | 18 | 18 | 3 | 25 | 55 | 0 | 28 | 3 | 0 | 0 | 0 | 11 | 3.07 |
| SP | Greinke, Z.Greinke, Zack † | Bees | R | 95.0 | 26 | 26 | 13 | 9 | 3.61 | .270 | 1.07 | 7.3 | 2.3 | 7.7 | 184.2 | 149 | 74 | 74 | 27 | 48 | 158 | 4 | 0 | 0 | 3 | 13 | 8 | 3 | 4.10 |
| SP | Bieber, S.Bieber, Shane # | Bees | R | 95.0 | 24 | 24 | 13 | 7 | 3.49 | .267 | 1.07 | 7.5 | 2.1 | 10.5 | 167.2 | 140 | 70 | 65 | 27 | 39 | 194 | 1 | 0 | 0 | 0 | 17 | 4 | 6 | 3.55 |
| SP | Kershaw, C.Kershaw, Clayton † | Yadier Molinas | L | 89.0 | 26 | 26 | 10 | 9 | 3.35 | .280 | 1.12 | 8.1 | 2.0 | 9.8 | 180.0 | 161 | 68 | 67 | 22 | 40 | 195 | 7 | 0 | 0 | 1 | 19 | 9 | 7 | 3.24 |