| RP | Eckersley, D.Eckersley, Dennis † | Athletics | R | 111.0 | 49 | 0 | 16 | 2 | 2.22 | .276 | 1.12 | 8.7 | 1.3 | 6.9 | 69.0 | 67 | 19 | 17 | 4 | 10 | 53 | 0 | 4 | 0 | 0 | 0 | 2 | 0 | 2.74 |
| SP | Hunter, C.Hunter, Catfish † | Athletics | R | 111.0 | 20 | 20 | 13 | 6 | 2.63 | .271 | 1.11 | 6.8 | 3.2 | 4.5 | 161.0 | 122 | 49 | 47 | 9 | 57 | 80 | 9 | 0 | 0 | 1 | 16 | 1 | 2 | 3.81 |
| SP | Bender, C.Bender, Chief † | Athletics | R | 94.0 | 19 | 19 | 11 | 5 | 3.05 | .283 | 1.17 | 8.2 | 2.4 | 5.5 | 153.2 | 139 | 64 | 52 | 8 | 41 | 93 | 9 | 0 | 0 | 0 | 14 | 2 | 6 | 3.31 |
| CL | Hamilton, S.Hamilton, Steve † | Bums | L | 93.0 | 38 | 0 | 6 | 1 | 2.41 | .297 | 1.24 | 7.9 | 3.3 | 5.0 | 41.0 | 36 | 12 | 11 | 3 | 15 | 23 | 0 | 22 | 2 | 0 | 0 | 1 | 0 | 4.00 |
| SP | Cueto, J.Cueto, Johnny † # | Reds | R | 91.0 | 19 | 19 | 12 | 3 | 3.36 | .273 | 1.11 | 7.9 | 2.1 | 5.5 | 147.1 | 129 | 55 | 55 | 10 | 34 | 90 | 3 | 0 | 0 | 1 | 14 | 3 | 0 | 3.41 |
| SP | Koufax, S.Koufax, Sandy † | Dodgers | L | 89.0 | 20 | 20 | 9 | 5 | 2.90 | .281 | 1.17 | 7.6 | 3.0 | 8.9 | 158.1 | 133 | 53 | 51 | 13 | 52 | 156 | 4 | 0 | 0 | 1 | 14 | 1 | 3 | 3.10 |
| CL | Chapman, A.Chapman, Aroldis † | Reds | L | 85.0 | 42 | 0 | 2 | 4 | 1.83 | .249 | 0.97 | 3.1 | 5.7 | 12.3 | 44.1 | 15 | 11 | 9 | 0 | 28 | 60 | 0 | 26 | 2 | 0 | 0 | 1 | 2 | 2.25 |
| SP | Samardzija, J.Samardzija, Jeff † | Athletics | R | 82.0 | 19 | 19 | 11 | 4 | 3.38 | .283 | 1.16 | 8.9 | 1.5 | 7.0 | 130.1 | 129 | 51 | 49 | 7 | 22 | 101 | 4 | 0 | 0 | 0 | 13 | 3 | 3 | 2.72 |