| SP | Hunter, C.Hunter, Catfish † | Athletics | R | 164.0 | 29 | 29 | 20 | 4 | 3.19 | .279 | 1.14 | 7.6 | 2.8 | 5.3 | 231.2 | 194 | 89 | 82 | 16 | 71 | 135 | 12 | 0 | 0 | 3 | 20 | 4 | 3 | 3.71 |
| SP | McNally, D.McNally, Dave † # | Orioles | L | 155.0 | 29 | 29 | 19 | 6 | 2.90 | .303 | 1.27 | 9.0 | 2.5 | 5.5 | 226.2 | 226 | 75 | 73 | 17 | 62 | 138 | 8 | 0 | 0 | 1 | 20 | 8 | 0 | 3.69 |
| RP | Kolek, S.Kolek, Stephen † | Royals | R | 155.0 | 76 | 0 | 16 | 7 | 2.01 | .254 | 1.00 | 6.9 | 2.2 | 5.0 | 174.1 | 133 | 40 | 39 | 8 | 42 | 96 | 0 | 10 | 1 | 0 | 0 | 3 | 0 | 3.27 |
| RP | deGrom, J.deGrom, Jacob † | Mets | R | 138.5 | 71 | 0 | 10 | 4 | 1.85 | .230 | 0.89 | 6.0 | 2.1 | 8.5 | 131.2 | 87 | 28 | 27 | 7 | 30 | 123 | 0 | 17 | 1 | 0 | 0 | 1 | 0 | 2.53 |
| SP | Bender, C.Bender, Chief † | Athletics | R | 136.0 | 28 | 28 | 18 | 6 | 3.66 | .294 | 1.23 | 8.2 | 2.9 | 5.1 | 211.2 | 193 | 91 | 86 | 13 | 68 | 120 | 15 | 0 | 0 | 2 | 16 | 4 | 5 | 3.69 |
| RP | Kimbrel, C.Kimbrel, Craig † | Cu6s | R | 136.0 | 72 | 0 | 17 | 3 | 2.27 | .267 | 1.08 | 5.5 | 4.3 | 9.8 | 95.1 | 58 | 25 | 24 | 4 | 45 | 103 | 0 | 10 | 4 | 0 | 0 | 1 | 5 | 2.83 |
| RP | Hudson, B.Hudson, Bryan † | Brewers | L | 135.0 | 79 | 0 | 17 | 2 | 2.46 | .271 | 1.10 | 6.6 | 3.3 | 8.7 | 139.0 | 102 | 44 | 38 | 11 | 51 | 134 | 0 | 2 | 1 | 0 | 0 | 2 | 2 | 3.24 |
| SP | Scherzer, M.Scherzer, Max | Mets | R | 120.0 | 28 | 28 | 13 | 7 | 2.68 | .252 | 1.00 | 6.9 | 2.1 | 8.3 | 198.0 | 151 | 60 | 59 | 19 | 47 | 183 | 3 | 0 | 0 | 0 | 20 | 2 | 2 | 3.14 |