| SP | Rodon, C.Rodon, Carlos $$ | White Sox | L | 142.0 | 40 | 40 | 19 | 9 | 3.21 | .290 | 1.18 | 7.3 | 3.3 | 11.1 | 218.2 | 177 | 87 | 78 | 19 | 81 | 270 | 0 | 0 | 0 | 0 | 20 | 10 | 7 | 2.91 |
| RP | Lopez, R.Lopez, Reynaldo $$ | White Sox | R | 137.0 | 92 | 0 | 14 | 6 | 3.18 | .250 | 0.99 | 6.6 | 2.3 | 8.4 | 164.0 | 120 | 63 | 58 | 20 | 42 | 153 | 0 | 16 | 6 | 0 | 0 | 2 | 5 | 3.52 |
| SP | Humber, B.Humber, Bill # $$ | Rays | L | 136.0 | 35 | 35 | 19 | 9 | 3.85 | .274 | 1.09 | 7.4 | 2.4 | 6.4 | 247.2 | 204 | 108 | 106 | 35 | 66 | 176 | 10 | 0 | 0 | 4 | 18 | 10 | 10 | 4.34 |
| CL | Rodriguez, B.Rodriguez, Bill $$ | Blue Jays | R | 121.5 | 54 | 0 | 1 | 2 | 2.68 | .237 | 0.85 | 5.2 | 2.5 | 8.8 | 50.1 | 29 | 15 | 15 | 5 | 14 | 49 | 0 | 43 | 3 | 0 | 0 | 4 | 0 | 3.42 |
| SP | Johnson, G.Johnson, Greg $$ | Angels | L | 120.0 | 35 | 35 | 19 | 10 | 3.86 | .296 | 1.23 | 7.9 | 3.1 | 6.9 | 233.0 | 205 | 103 | 100 | 39 | 81 | 179 | 2 | 0 | 0 | 0 | 22 | 8 | 4 | 4.79 |
| RP | Javier, C.Javier, Cristian $$ | Astros | R | 118.5 | 87 | 0 | 9 | 6 | 3.44 | .304 | 1.27 | 6.3 | 5.2 | 10.6 | 167.2 | 116 | 74 | 64 | 19 | 97 | 197 | 0 | 19 | 6 | 0 | 0 | 7 | 4 | 3.99 |
| SP | Carlin, S.Carlin, Steven $$ | Blue Jays | L | 111.0 | 35 | 35 | 20 | 8 | 4.72 | .340 | 1.50 | 9.2 | 4.3 | 7.5 | 242.0 | 248 | 132 | 127 | 34 | 116 | 203 | 4 | 0 | 0 | 0 | 17 | 10 | 2 | 4.71 |
| SP | Cuizon, N.Cuizon, Noel $$ | Mariners | R | 109.0 | 36 | 36 | 15 | 8 | 3.73 | .310 | 1.31 | 8.0 | 3.8 | 10.0 | 212.1 | 189 | 97 | 88 | 24 | 90 | 236 | 1 | 0 | 0 | 1 | 22 | 7 | 3 | 3.62 |