| CL | Doolittle, S.Doolittle, Sean † | FrOGGIES | L | 109.0 | 63 | 0 | 5 | 1 | 1.62 | .204 | 0.77 | 5.1 | 1.8 | 8.5 | 78.0 | 44 | 16 | 14 | 3 | 16 | 74 | 0 | 22 | 4 | 0 | 0 | 0 | 3 | 2.22 |
| SP | Leonard, D.Leonard, Dutch † | Violets | L | 102.0 | 24 | 24 | 13 | 6 | 2.99 | .261 | 1.03 | 5.9 | 3.4 | 5.5 | 159.2 | 105 | 54 | 53 | 14 | 60 | 97 | 3 | 0 | 0 | 3 | 18 | 4 | 0 | 4.13 |
| SP | Koufax, S.Koufax, Sandy † # | Eagles | L | 101.0 | 24 | 24 | 12 | 10 | 3.15 | .231 | 0.88 | 6.3 | 1.7 | 7.5 | 180.0 | 126 | 66 | 63 | 17 | 33 | 149 | 10 | 0 | 0 | 2 | 16 | 3 | 1 | 3.17 |
| SP | Verlander, J.Verlander, Justin | Grasshoppers | R | 97.0 | 25 | 25 | 13 | 9 | 3.58 | .264 | 1.05 | 7.0 | 2.4 | 8.5 | 183.2 | 143 | 75 | 73 | 24 | 49 | 172 | 7 | 0 | 0 | 1 | 15 | 6 | 2 | 3.73 |
| SP | Gibson, B.Gibson, Bob # $ | Warriors | R | 91.0 | 23 | 23 | 13 | 9 | 3.89 | .285 | 1.17 | 8.2 | 2.3 | 6.2 | 171.1 | 156 | 79 | 74 | 18 | 44 | 118 | 12 | 0 | 0 | 2 | 11 | 5 | 3 | 3.85 |
| SP | Fernandez, S.Fernandez, Sid $$ | Eagles | L | 91.0 | 23 | 23 | 12 | 8 | 3.07 | .279 | 1.13 | 5.7 | 4.5 | 7.4 | 161.1 | 102 | 61 | 55 | 13 | 81 | 132 | 1 | 0 | 0 | 1 | 15 | 4 | 1 | 3.99 |
| SP | Martinez, P.Martinez, Pedro † $ | Warriors | R | 91.0 | 25 | 25 | 10 | 9 | 3.37 | .266 | 1.08 | 8.0 | 1.7 | 8.0 | 192.1 | 171 | 85 | 72 | 21 | 37 | 171 | 9 | 0 | 0 | 2 | 15 | 1 | 2 | 3.23 |
| SP | Mathewson, C.Mathewson, Christy | Violets | R | 90.0 | 23 | 23 | 9 | 4 | 2.75 | .252 | 1.01 | 7.5 | 1.5 | 4.5 | 157.0 | 131 | 58 | 48 | 12 | 27 | 79 | 5 | 0 | 0 | 3 | 18 | 1 | 2 | 3.52 |