| SP | Gibson, B.Gibson, Bob † # | CardiNGals 1171 | R | 145.0 | 23 | 23 | 17 | 4 | 2.96 | .257 | 0.99 | 6.8 | 2.2 | 6.0 | 182.1 | 137 | 64 | 60 | 13 | 44 | 121 | 13 | 0 | 0 | 4 | 15 | 8 | 2 | 3.46 |
| SP | Chamberlain, E.Chamberlain, Elton † | CardiNGals 1171 | R | 136.0 | 22 | 22 | 15 | 6 | 2.81 | .295 | 1.24 | 7.7 | 3.5 | 6.6 | 182.1 | 156 | 60 | 57 | 13 | 70 | 134 | 13 | 0 | 0 | 5 | 14 | 3 | 0 | 3.66 |
| SP | Greinke, Z.Greinke, Zack † | Astros | R | 102.0 | 21 | 21 | 12 | 2 | 2.88 | .238 | 0.91 | 6.6 | 1.6 | 7.0 | 144.0 | 105 | 49 | 46 | 16 | 26 | 112 | 3 | 0 | 0 | 0 | 14 | 4 | 1 | 3.51 |
| CL | Chapman, A.Chapman, Aroldis † | Northsiders | L | 92.5 | 48 | 0 | 4 | 1 | 2.68 | .255 | 1.02 | 5.8 | 3.6 | 10.5 | 53.2 | 34 | 18 | 16 | 3 | 21 | 62 | 0 | 23 | 1 | 0 | 0 | 0 | 4 | 2.58 |
| CL | Pressly, R.Pressly, Ryan † | Astros | R | 88.5 | 46 | 0 | 3 | 2 | 3.33 | .296 | 1.26 | 6.8 | 4.5 | 9.6 | 46.0 | 35 | 17 | 17 | 5 | 23 | 49 | 0 | 27 | 2 | 0 | 0 | 0 | 0 | 3.78 |
| SP | Verlander, J.Verlander, Justin † | Astros | R | 83.0 | 22 | 22 | 11 | 3 | 3.77 | .293 | 1.24 | 7.9 | 3.3 | 10.2 | 140.2 | 123 | 60 | 59 | 13 | 51 | 159 | 2 | 0 | 0 | 1 | 14 | 1 | 2 | 3.05 |