| SP | Gibson, B.Gibson, Bob † # | CardiNGals 1171 | R | 195.0 | 36 | 36 | 23 | 10 | 3.10 | .277 | 1.11 | 7.8 | 2.2 | 6.2 | 281.2 | 243 | 107 | 97 | 22 | 69 | 193 | 20 | 0 | 0 | 5 | 24 | 12 | 2 | 3.51 |
| SP | Greinke, Z.Greinke, Zack † | Astros | R | 163.0 | 33 | 33 | 21 | 3 | 3.12 | .248 | 0.96 | 7.2 | 1.5 | 7.0 | 222.0 | 177 | 81 | 77 | 22 | 37 | 173 | 4 | 0 | 0 | 0 | 23 | 6 | 1 | 3.31 |
| SP | Verlander, J.Verlander, Justin † | Astros | R | 159.0 | 36 | 36 | 20 | 5 | 3.30 | .278 | 1.14 | 7.5 | 2.8 | 10.1 | 231.2 | 193 | 86 | 85 | 23 | 71 | 258 | 3 | 0 | 0 | 2 | 24 | 4 | 2 | 3.03 |
| CL | Chapman, A.Chapman, Aroldis † | Northsiders | L | 146.0 | 81 | 0 | 7 | 5 | 3.10 | .267 | 1.08 | 6.2 | 3.5 | 10.1 | 87.0 | 60 | 32 | 30 | 6 | 34 | 98 | 0 | 40 | 5 | 0 | 0 | 1 | 6 | 2.85 |
| CL | Pressly, R.Pressly, Ryan † | Astros | R | 139.0 | 76 | 0 | 4 | 3 | 3.59 | .274 | 1.13 | 6.8 | 3.5 | 10.4 | 77.2 | 58 | 31 | 31 | 9 | 30 | 89 | 0 | 44 | 3 | 0 | 0 | 0 | 0 | 3.38 |
| SP | Chamberlain, E.Chamberlain, Elton † | CardiNGals 1171 | R | 130.0 | 35 | 35 | 18 | 11 | 3.99 | .318 | 1.38 | 9.1 | 3.3 | 6.6 | 252.2 | 255 | 124 | 112 | 23 | 93 | 184 | 14 | 0 | 0 | 5 | 16 | 5 | 0 | 3.89 |