| SP | Santana, J.Santana, Johan † # | Sluggers | L | 168.0 | 30 | 30 | 21 | 4 | 2.81 | .248 | 0.98 | 6.7 | 2.1 | 9.1 | 214.2 | 160 | 68 | 67 | 18 | 51 | 216 | 1 | 0 | 0 | 1 | 22 | 1 | 1 | 2.80 |
| CL | Papelbon, J.Papelbon, Jonathan † | Mountain Lions | R | 133.0 | 67 | 0 | 8 | 3 | 2.60 | .258 | 1.03 | 6.8 | 2.5 | 9.3 | 79.2 | 60 | 25 | 23 | 3 | 22 | 82 | 0 | 30 | 2 | 0 | 0 | 1 | 1 | 2.29 |
| CL | Gagne, E.Gagne, Eric † $$ | Sharks | R | 118.5 | 61 | 0 | 2 | 5 | 2.43 | .289 | 1.20 | 7.2 | 3.8 | 10.3 | 55.2 | 44 | 19 | 15 | 5 | 23 | 63 | 0 | 41 | 4 | 0 | 0 | 1 | 3 | 3.20 |
| CL | Wagner, B.Wagner, Billy † $$ | Monarchs | L | 117.5 | 63 | 0 | 6 | 6 | 3.13 | .276 | 1.13 | 6.8 | 3.4 | 8.7 | 69.0 | 52 | 24 | 24 | 10 | 26 | 67 | 0 | 33 | 2 | 0 | 0 | 1 | 2 | 4.12 |
| SP | Clemens, R.Clemens, Roger | Horses | R | 117.0 | 30 | 30 | 14 | 12 | 2.84 | .271 | 1.10 | 6.8 | 3.0 | 5.7 | 225.0 | 171 | 78 | 71 | 27 | 76 | 143 | 4 | 0 | 0 | 2 | 20 | 4 | 3 | 4.36 |
| CL | Rivera, M.Rivera, Mariano † | Sluggers | R | 114.0 | 64 | 0 | 3 | 3 | 4.45 | .287 | 1.18 | 8.1 | 2.6 | 9.9 | 58.2 | 52 | 31 | 29 | 10 | 17 | 64 | 0 | 40 | 3 | 0 | 0 | 2 | 1 | 4.02 |
| SP | Halladay, R.Halladay, Roy † | Monarchs | R | 104.0 | 30 | 30 | 13 | 10 | 3.37 | .273 | 1.11 | 8.4 | 1.6 | 7.1 | 213.2 | 199 | 87 | 80 | 31 | 39 | 168 | 5 | 0 | 0 | 2 | 18 | 3 | 6 | 3.91 |
| RP | Soriano, R.Soriano, Rafael † | Frogs | R | 103.0 | 81 | 0 | 13 | 2 | 3.88 | .311 | 1.34 | 9.3 | 2.7 | 9.5 | 118.1 | 122 | 52 | 51 | 9 | 36 | 125 | 0 | 8 | 2 | 0 | 0 | 2 | 0 | 2.84 |
| SP | Martinez, P.Martinez, Pedro $ | Sharks | R | 100.0 | 30 | 30 | 13 | 13 | 3.41 | .290 | 1.20 | 7.8 | 3.0 | 9.2 | 219.1 | 191 | 88 | 83 | 27 | 72 | 225 | 4 | 0 | 0 | 1 | 20 | 6 | 4 | 3.62 |