| SP | Martinez, P.Martinez, Pedro † # | Gorillas | R | 144.0 | 29 | 29 | 13 | 5 | 2.43 | .246 | 0.96 | 6.8 | 1.9 | 10.1 | 218.2 | 164 | 60 | 59 | 21 | 47 | 244 | 4 | 0 | 0 | 3 | 23 | 3 | 0 | 2.70 |
| SP | Maddux, G.Maddux, Greg † $ | Charlie Browns | R | 127.0 | 28 | 28 | 18 | 5 | 3.68 | .290 | 1.21 | 8.6 | 2.2 | 5.1 | 203.0 | 195 | 83 | 83 | 22 | 50 | 116 | 8 | 0 | 0 | 1 | 17 | 4 | 3 | 4.06 |
| SP | Verlander, J.Verlander, Justin | Wolf Pack | R | 110.0 | 28 | 28 | 12 | 6 | 2.92 | .282 | 1.16 | 7.3 | 3.2 | 9.6 | 197.1 | 159 | 67 | 64 | 23 | 69 | 211 | 0 | 0 | 0 | 0 | 23 | 4 | 4 | 3.49 |
| CL | Kimbrel, C.Kimbrel, Craig † | Wolf Pack | R | 109.5 | 53 | 0 | 3 | 2 | 2.55 | .256 | 1.03 | 6.0 | 3.3 | 10.1 | 60.0 | 40 | 18 | 17 | 7 | 22 | 67 | 0 | 33 | 5 | 0 | 0 | 0 | 4 | 3.38 |
| SP | Fernandez, S.Fernandez, Sid † | Red Bulls | L | 107.0 | 26 | 26 | 13 | 6 | 3.07 | .303 | 1.28 | 7.0 | 4.5 | 9.1 | 176.0 | 137 | 63 | 60 | 14 | 88 | 177 | 2 | 0 | 0 | 1 | 18 | 5 | 4 | 3.61 |
| SP | Fernandez, J.Fernandez, Jose | Red Bulls | R | 106.0 | 27 | 27 | 15 | 5 | 3.45 | .326 | 1.43 | 8.5 | 4.3 | 9.6 | 159.0 | 151 | 63 | 61 | 13 | 76 | 170 | 0 | 0 | 0 | 0 | 20 | 4 | 3 | 3.43 |
| SP | deGrom, J.deGrom, Jacob † | Pumas | R | 101.0 | 29 | 29 | 14 | 7 | 3.52 | .281 | 1.15 | 8.6 | 1.8 | 10.8 | 176.2 | 168 | 72 | 69 | 30 | 35 | 212 | 0 | 0 | 0 | 0 | 20 | 4 | 0 | 3.47 |
| SP | Scherzer, M.Scherzer, Max † | Titans | R | 99.0 | 29 | 29 | 15 | 7 | 3.87 | .298 | 1.25 | 8.7 | 2.6 | 9.7 | 160.2 | 154 | 72 | 69 | 24 | 47 | 172 | 3 | 0 | 0 | 2 | 12 | 4 | 4 | 3.76 |
| SP | Saberhagen, B.Saberhagen, Bret | Pumas | R | 98.0 | 27 | 27 | 15 | 5 | 4.06 | .313 | 1.33 | 9.1 | 2.9 | 6.6 | 177.1 | 179 | 82 | 80 | 30 | 57 | 130 | 5 | 0 | 0 | 0 | 17 | 6 | 0 | 4.80 |