| SP | Harvey, M.Harvey, Matt † # | Gators | R | 175.0 | 34 | 34 | 23 | 5 | 3.39 | .279 | 1.14 | 8.6 | 1.7 | 9.8 | 241.1 | 229 | 95 | 91 | 29 | 45 | 262 | 5 | 0 | 0 | 2 | 25 | 6 | 5 | 3.02 |
| SP | Arrieta, J.Arrieta, Jake † | Phillies | R | 160.0 | 32 | 32 | 20 | 6 | 3.02 | .270 | 1.08 | 7.0 | 2.7 | 9.3 | 220.2 | 172 | 75 | 74 | 21 | 66 | 228 | 4 | 0 | 0 | 1 | 25 | 7 | 7 | 3.16 |
| SP | Verlander, J.Verlander, Justin | Kraken | R | 132.0 | 36 | 36 | 16 | 13 | 3.26 | .274 | 1.09 | 7.3 | 2.6 | 10.0 | 256.2 | 208 | 94 | 93 | 31 | 73 | 284 | 4 | 0 | 0 | 2 | 24 | 10 | 2 | 3.33 |
| SP | Kershaw, C.Kershaw, Clayton | Sloths | L | 119.0 | 34 | 34 | 17 | 11 | 4.05 | .298 | 1.25 | 9.5 | 1.7 | 9.6 | 253.1 | 267 | 118 | 114 | 39 | 49 | 271 | 6 | 0 | 0 | 2 | 18 | 7 | 3 | 3.53 |
| CL | Doolittle, S.Doolittle, Sean † | Labias | L | 115.0 | 89 | 0 | 2 | 5 | 3.36 | .276 | 1.11 | 7.0 | 3.0 | 9.5 | 91.0 | 71 | 36 | 34 | 7 | 30 | 96 | 0 | 40 | 9 | 0 | 0 | 3 | 3 | 2.98 |
| CL | Kimbrel, C.Kimbrel, Craig † | Phillies | R | 115.0 | 58 | 0 | 1 | 4 | 3.58 | .278 | 1.10 | 6.9 | 3.1 | 10.8 | 55.1 | 42 | 23 | 22 | 5 | 19 | 66 | 0 | 44 | 5 | 0 | 0 | 3 | 4 | 2.98 |
| RP | Chapman, A.Chapman, Aroldis † | Dragons | L | 114.5 | 87 | 0 | 13 | 0 | 2.96 | .261 | 1.03 | 6.0 | 3.3 | 10.9 | 121.2 | 81 | 41 | 40 | 13 | 44 | 147 | 0 | 5 | 2 | 0 | 0 | 4 | 4 | 3.16 |
| SP | Strasburg, S.Strasburg, Stephen † # | Labias | R | 114.0 | 34 | 34 | 18 | 7 | 4.09 | .306 | 1.31 | 9.0 | 2.8 | 9.9 | 198.0 | 197 | 94 | 90 | 25 | 62 | 217 | 0 | 0 | 0 | 0 | 22 | 3 | 6 | 3.43 |