| SP | McGinnity, J.McGinnity, Joe † | Giants | R | 287.0 | 61 | 61 | 36 | 15 | 3.41 | .294 | 1.22 | 8.6 | 2.3 | 2.8 | 509.0 | 489 | 208 | 193 | 5 | 132 | 159 | 32 | 0 | 0 | 3 | 32 | 16 | 7 | 3.38 |
| SP | Waddell, R.Waddell, Rube † + | Pirates | L | 235.0 | 60 | 60 | 29 | 24 | 3.33 | .291 | 1.21 | 8.3 | 2.6 | 4.6 | 469.2 | 433 | 200 | 174 | 7 | 135 | 240 | 27 | 0 | 0 | 5 | 39 | 11 | 13 | 3.10 |
| SP | O'Neill, M.O'Neill, Mike † + | Cardinals | R | 207.0 | 56 | 56 | 24 | 22 | 3.21 | .302 | 1.27 | 8.8 | 2.7 | 3.0 | 446.1 | 436 | 193 | 159 | 4 | 132 | 151 | 28 | 0 | 0 | 3 | 36 | 10 | 0 | 3.39 |
| SP | Taylor, D.Taylor, Dummy † | Giants | R | 203.0 | 53 | 53 | 27 | 19 | 3.73 | .302 | 1.25 | 8.8 | 2.5 | 3.3 | 429.1 | 420 | 199 | 178 | 6 | 118 | 159 | 28 | 0 | 0 | 5 | 27 | 20 | 12 | 3.41 |
| SP | Tannehill, J.Tannehill, Jesse † + | Pirates | L | 190.0 | 53 | 53 | 28 | 18 | 3.92 | .310 | 1.30 | 9.5 | 2.2 | 2.8 | 402.0 | 426 | 188 | 175 | 4 | 97 | 127 | 25 | 0 | 0 | 3 | 28 | 19 | 0 | 3.36 |
| SP | Donovan, B.Donovan, Bill † | Real Prog. | R | 186.0 | 55 | 55 | 25 | 17 | 3.74 | .304 | 1.28 | 8.6 | 3.0 | 3.6 | 390.0 | 371 | 186 | 162 | 11 | 129 | 156 | 24 | 0 | 0 | 4 | 32 | 11 | 13 | 3.64 |
| SP | Winters, R.Winters, Rube † + | Real Prog. | L | 180.0 | 55 | 55 | 25 | 20 | 3.48 | .321 | 1.39 | 9.6 | 2.9 | 3.5 | 410.2 | 439 | 198 | 159 | 7 | 130 | 160 | 12 | 0 | 0 | 2 | 33 | 14 | 7 | 3.50 |
| SP | Newton, D.Newton, Doc # + | Reds | L | 171.0 | 56 | 56 | 25 | 26 | 3.73 | .323 | 1.39 | 9.0 | 3.5 | 2.9 | 434.2 | 432 | 215 | 180 | 5 | 171 | 139 | 23 | 0 | 0 | 3 | 30 | 19 | 8 | 3.82 |
| SP | Dinneen, W.Dinneen, William # + | Beaneaters | R | 171.0 | 49 | 49 | 24 | 21 | 3.65 | .309 | 1.31 | 9.2 | 2.6 | 2.9 | 386.2 | 396 | 177 | 157 | 7 | 110 | 124 | 24 | 0 | 0 | 2 | 29 | 13 | 5 | 3.55 |