| SP | Chamberlain, E.Chamberlain, Elton † | Cardinals | R | 172.0 | 30 | 30 | 19 | 9 | 2.66 | .273 | 1.11 | 6.6 | 3.4 | 5.4 | 250.1 | 183 | 85 | 74 | 16 | 95 | 151 | 16 | 0 | 0 | 3 | 21 | 4 | 0 | 3.81 |
| SP | Flaherty, J.Flaherty, Jack † | Cardinals | R | 156.0 | 29 | 29 | 19 | 3 | 2.60 | .258 | 1.03 | 6.5 | 2.7 | 8.7 | 197.0 | 142 | 58 | 57 | 11 | 60 | 191 | 0 | 0 | 0 | 0 | 24 | 3 | 3 | 2.75 |
| SP | Richard, J.Richard, J.R. # | Astr6s | R | 123.0 | 28 | 28 | 16 | 6 | 3.31 | .273 | 1.12 | 6.6 | 3.5 | 8.2 | 193.1 | 141 | 74 | 71 | 18 | 75 | 176 | 4 | 0 | 0 | 1 | 20 | 2 | 4 | 3.59 |
| SP | Arrieta, J.Arrieta, Jake † | Cubs | R | 121.0 | 29 | 29 | 16 | 6 | 3.57 | .304 | 1.29 | 9.4 | 2.3 | 8.7 | 204.0 | 212 | 95 | 81 | 20 | 51 | 198 | 5 | 0 | 0 | 0 | 19 | 4 | 3 | 3.14 |
| RP | Gossage, R.Gossage, Rich † | YaNGks 1007 WAR | R | 116.0 | 84 | 0 | 13 | 1 | 2.58 | .281 | 1.16 | 6.7 | 3.8 | 9.0 | 108.1 | 80 | 33 | 31 | 7 | 46 | 108 | 0 | 6 | 0 | 0 | 0 | 1 | 5 | 3.15 |
| SP | Marichal, J.Marichal, Juan | Gaints | R | 114.0 | 30 | 30 | 15 | 8 | 3.87 | .283 | 1.16 | 8.3 | 2.1 | 5.9 | 235.0 | 218 | 101 | 101 | 26 | 54 | 154 | 13 | 0 | 0 | 1 | 17 | 6 | 2 | 3.89 |
| RP | Kimbrel, C.Kimbrel, Craig † | Cubs | R | 106.0 | 79 | 0 | 16 | 2 | 3.05 | .303 | 1.26 | 4.9 | 6.5 | 9.5 | 97.1 | 53 | 37 | 33 | 5 | 70 | 102 | 0 | 2 | 3 | 0 | 0 | 4 | 1 | 3.86 |
| RP | Sanchez, A.Sanchez, Aaron | Blue Jays 1 | R | 100.5 | 76 | 0 | 12 | 4 | 2.61 | .267 | 1.08 | 6.2 | 3.5 | 6.0 | 134.2 | 93 | 40 | 39 | 9 | 52 | 89 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 3.75 |