| SP | Chamberlain, E.Chamberlain, Elton † | Cardinals | R | 148.0 | 25 | 25 | 16 | 7 | 2.60 | .271 | 1.10 | 6.5 | 3.4 | 5.8 | 207.1 | 150 | 69 | 60 | 16 | 79 | 133 | 13 | 0 | 0 | 3 | 18 | 2 | 0 | 3.89 |
| SP | Flaherty, J.Flaherty, Jack † | Cardinals | R | 126.0 | 24 | 24 | 15 | 2 | 2.64 | .258 | 1.03 | 6.6 | 2.7 | 9.2 | 163.2 | 120 | 49 | 48 | 10 | 48 | 167 | 0 | 0 | 0 | 0 | 20 | 3 | 3 | 2.69 |
| SP | Richard, J.Richard, J.R. # | Astr6s | R | 116.0 | 23 | 23 | 14 | 4 | 2.95 | .268 | 1.09 | 6.6 | 3.2 | 8.0 | 164.2 | 120 | 57 | 54 | 12 | 59 | 145 | 4 | 0 | 0 | 1 | 18 | 2 | 3 | 3.30 |
| SP | Arrieta, J.Arrieta, Jake † | Cubs | R | 115.0 | 24 | 24 | 14 | 4 | 3.22 | .305 | 1.30 | 9.6 | 2.2 | 8.8 | 173.1 | 184 | 73 | 62 | 14 | 42 | 170 | 5 | 0 | 0 | 0 | 16 | 2 | 2 | 2.85 |
| RP | Gossage, R.Gossage, Rich † | YaNGks 1007 WAR | R | 97.5 | 68 | 0 | 11 | 1 | 2.30 | .271 | 1.10 | 6.6 | 3.3 | 9.5 | 86.0 | 63 | 24 | 22 | 5 | 32 | 91 | 0 | 5 | 0 | 0 | 0 | 1 | 5 | 2.79 |
| RP | Kimbrel, C.Kimbrel, Craig † | Cubs | R | 95.0 | 67 | 0 | 15 | 2 | 3.27 | .295 | 1.21 | 4.6 | 6.4 | 9.3 | 82.2 | 42 | 32 | 30 | 5 | 58 | 85 | 0 | 2 | 3 | 0 | 0 | 4 | 1 | 3.99 |
| SP | Marichal, J.Marichal, Juan | Gaints | R | 94.0 | 25 | 25 | 12 | 7 | 3.80 | .283 | 1.16 | 8.1 | 2.3 | 6.0 | 194.1 | 175 | 82 | 82 | 21 | 50 | 129 | 12 | 0 | 0 | 1 | 14 | 5 | 2 | 3.93 |
| RP | Sanchez, A.Sanchez, Aaron | Blue Jays 1 | R | 86.0 | 63 | 0 | 11 | 3 | 2.67 | .269 | 1.09 | 6.5 | 3.3 | 5.5 | 111.1 | 80 | 34 | 33 | 8 | 41 | 68 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 3.87 |