| SP | Chamberlain, E.Chamberlain, Elton † | Cardinals | R | 166.0 | 28 | 28 | 18 | 8 | 2.61 | .268 | 1.09 | 6.4 | 3.4 | 5.5 | 234.1 | 166 | 77 | 68 | 16 | 89 | 142 | 16 | 0 | 0 | 3 | 20 | 3 | 0 | 3.85 |
| SP | Flaherty, J.Flaherty, Jack † | Cardinals | R | 143.0 | 27 | 27 | 17 | 3 | 2.58 | .255 | 1.01 | 6.5 | 2.6 | 8.9 | 184.2 | 133 | 54 | 53 | 10 | 54 | 182 | 0 | 0 | 0 | 0 | 23 | 3 | 3 | 2.66 |
| SP | Arrieta, J.Arrieta, Jake † | Cubs | R | 125.0 | 27 | 27 | 16 | 5 | 3.32 | .303 | 1.29 | 9.4 | 2.3 | 8.7 | 192.1 | 200 | 84 | 71 | 18 | 48 | 185 | 5 | 0 | 0 | 0 | 18 | 3 | 3 | 3.09 |
| SP | Richard, J.Richard, J.R. # | Astr6s | R | 119.0 | 26 | 26 | 15 | 5 | 3.18 | .272 | 1.11 | 6.6 | 3.4 | 8.2 | 181.1 | 132 | 67 | 64 | 13 | 69 | 164 | 4 | 0 | 0 | 1 | 19 | 2 | 3 | 3.30 |
| RP | Gossage, R.Gossage, Rich † | YaNGks 1007 WAR | R | 108.0 | 78 | 0 | 12 | 1 | 2.53 | .278 | 1.14 | 6.7 | 3.6 | 9.2 | 99.2 | 74 | 30 | 28 | 6 | 40 | 101 | 0 | 6 | 0 | 0 | 0 | 1 | 5 | 2.99 |
| RP | Kimbrel, C.Kimbrel, Craig † | Cubs | R | 104.0 | 73 | 0 | 16 | 2 | 3.16 | .295 | 1.21 | 4.5 | 6.3 | 9.7 | 91.0 | 46 | 34 | 32 | 5 | 64 | 98 | 0 | 2 | 3 | 0 | 0 | 4 | 1 | 3.80 |
| SP | Marichal, J.Marichal, Juan | Gaints | R | 97.0 | 27 | 27 | 13 | 8 | 3.94 | .286 | 1.17 | 8.3 | 2.3 | 6.0 | 208.0 | 192 | 91 | 91 | 23 | 52 | 139 | 12 | 0 | 0 | 1 | 15 | 6 | 2 | 3.94 |
| RP | Sanchez, A.Sanchez, Aaron | Blue Jays 1 | R | 96.5 | 70 | 0 | 12 | 4 | 2.61 | .266 | 1.07 | 6.2 | 3.5 | 5.6 | 124.0 | 85 | 37 | 36 | 9 | 48 | 77 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 3.91 |