| SP | Hendricks, K.Hendricks, Kyle >> | 31 | 2021 | R | 27 | 14 | 7 | 4.77 | .306 | .350 | 1.35 | 9.9 | 2.2 | 6.5 | 181 | 200 | 31 | 44 | 131 | 1 | 0 | 2 | 100 | 16 | C |
| SP | Happ, J.Happ, J.A. >> | 39 | 2021 | L | 17 | 10 | 8 | 5.79 | .326 | .370 | 1.48 | 10.5 | 2.8 | 7.2 | 152 | 177 | 30 | 48 | 122 | 0 | 0 | 4 | 90 | 17 | C |
| SP | Lyles, J.Lyles, Jordan >> | 30 | 2021 | R | 25 | 10 | 13 | 5.15 | .313 | .350 | 1.39 | 9.7 | 2.8 | 7.3 | 180 | 194 | 38 | 56 | 146 | 0 | 0 | 9 | 100 | 17 | C |
| SP | Gutiérrez, V.Gutiérrez, Vladimir >> | 25 | 2021 | R | 28 | 9 | 6 | 4.74 | .314 | .360 | 1.41 | 9.1 | 3.6 | 6.9 | 114 | 115 | 20 | 46 | 88 | 0 | 0 | 3 | 92 | 17 | C |
| SP | Corbin, P.Corbin, Patrick >> | 31 | 2021 | L | 21 | 9 | 16 | 5.82 | .325 | .370 | 1.47 | 10.1 | 3.2 | 7.5 | 171 | 192 | 37 | 60 | 143 | 0 | 0 | 0 | 98 | 17 | C |
| SP | Keuchel, D.Keuchel, Dallas >> | 33 | 2021 | L | 13 | 9 | 9 | 5.28 | .333 | .380 | 1.53 | 10.5 | 3.3 | 5.3 | 162 | 189 | 25 | 59 | 95 | 0 | 0 | 5 | 90 | 15 | C |
| SP | Keller, B.Keller, Brad >> | 25 | 2021 | R | 9 | 8 | 12 | 5.39 | .352 | .400 | 1.67 | 10.7 | 4.3 | 8.1 | 133 | 158 | 18 | 64 | 120 | 0 | 0 | 5 | 91 | 18 | C |
| SP | Lester, J.Lester, Jon >> | 37 | 2021 | L | 14 | 7 | 6 | 4.71 | .331 | .370 | 1.52 | 10.1 | 3.5 | 5.8 | 141 | 159 | 25 | 55 | 91 | 0 | 0 | 0 | 90 | 16 | C |
| SP | Fedde, E.Fedde, Erick >> | 28 | 2021 | R | 26 | 7 | 9 | 5.47 | .319 | .360 | 1.44 | 9.7 | 3.2 | 8.7 | 133 | 144 | 23 | 48 | 128 | 0 | 0 | 1 | 82 | 19 | C |
| SP | Freeland, K.Freeland, Kyle >> | 28 | 2021 | L | 24 | 7 | 8 | 4.33 | .316 | .360 | 1.43 | 10.0 | 2.9 | 7.9 | 120 | 133 | 20 | 38 | 105 | 0 | 0 | 1 | 93 | 18 | C |
| SP | Richards, G.Richards, Garrett >> | 33 | 2021 | R | 13 | 7 | 8 | 4.87 | .343 | .390 | 1.60 | 10.5 | 4.0 | 7.6 | 136 | 158 | 19 | 60 | 115 | 0 | 3 | 7 | 62 | 17 | C |
| SP | Cueto, J.Cueto, Johnny >> | 35 | 2021 | R | 25 | 7 | 7 | 4.08 | .308 | .350 | 1.38 | 10.0 | 2.4 | 7.7 | 114 | 127 | 15 | 30 | 98 | 0 | 0 | 0 | 92 | 18 | C |
| SP | Sheffield, J.Sheffield, Justus >> | 25 | 2021 | L | 1 | 7 | 8 | 6.83 | .372 | .420 | 1.85 | 11.8 | 4.8 | 7.1 | 80 | 105 | 14 | 43 | 63 | 0 | 0 | 5 | 69 | 17 | C |
| SP | Davies, Z.Davies, Zach >> | 28 | 2021 | R | 15 | 6 | 12 | 5.78 | .343 | .390 | 1.60 | 9.9 | 4.6 | 6.9 | 148 | 162 | 25 | 75 | 114 | 0 | 0 | 0 | 83 | 17 | C |
| SP | Harvey, M.Harvey, Matt >> | 32 | 2021 | R | 11 | 6 | 14 | 6.27 | .335 | .380 | 1.55 | 11.3 | 2.6 | 6.7 | 127 | 160 | 19 | 37 | 95 | 0 | 0 | 3 | 81 | 16 | C |
| SP | Mills, A.Mills, Alec >> | 29 | 2021 | R | 20 | 6 | 7 | 5.07 | .318 | .360 | 1.44 | 10.4 | 2.6 | 6.6 | 119 | 137 | 16 | 34 | 87 | 0 | 1 | 4 | 67 | 16 | C |
| SP | Luzardo, J.Luzardo, Jesus >> | 23 | 2021 | L | 18 | 6 | 9 | 6.61 | .343 | .390 | 1.62 | 10.0 | 4.5 | 9.3 | 95 | 106 | 20 | 48 | 98 | 0 | 0 | 8 | 69 | 19 | C |
| SP | Singer, B.Singer, Brady >> | 24 | 2021 | R | 20 | 5 | 10 | 4.91 | .336 | .380 | 1.55 | 10.3 | 3.7 | 9.2 | 128 | 146 | 14 | 53 | 131 | 1 | 0 | 3 | 85 | 19 | C |
| SP | Canning, G.Canning, Griffin >> | 25 | 2021 | R | 26 | 5 | 4 | 5.60 | .322 | .370 | 1.50 | 9.4 | 4.1 | 9.0 | 62 | 65 | 14 | 28 | 62 | 0 | 0 | 3 | 79 | 20 | C |
| SP | Arrieta, J.Arrieta, Jake >> | 35 | 2021 | R | 2 | 5 | 14 | 7.39 | .365 | .410 | 1.79 | 12.0 | 4.0 | 7.6 | 98 | 131 | 24 | 44 | 83 | 0 | 0 | 3 | 73 | 18 | C |
| SP | Dunning, D.Dunning, Dane >> | 26 | 2021 | R | 27 | 5 | 10 | 4.51 | .319 | .360 | 1.44 | 9.7 | 3.3 | 8.8 | 117 | 126 | 13 | 43 | 114 | 0 | 0 | 8 | 78 | 18 | C |
| SP | Keller, M.Keller, Mitch >> | 25 | 2021 | R | 5 | 5 | 11 | 6.17 | .367 | .410 | 1.80 | 11.8 | 4.4 | 8.3 | 100 | 131 | 10 | 49 | 92 | 0 | 0 | 2 | 78 | 18 | C |
| SP | Senzatela, A.Senzatela, Antonio >> | 26 | 2021 | R | 24 | 4 | 10 | 4.42 | .305 | .350 | 1.35 | 10.3 | 1.8 | 6.1 | 156 | 178 | 12 | 32 | 105 | 0 | 0 | 4 | 99 | 16 | C |
| SP | Manning, M.Manning, Matt >> | 23 | 2021 | R | 15 | 4 | 7 | 5.80 | .327 | .370 | 1.52 | 10.2 | 3.5 | 6.0 | 85 | 96 | 10 | 33 | 57 | 0 | 0 | 1 | 84 | 16 | C |
| SP | Urena, J.Urena, Jose >> | 29 | 2021 | R | 9 | 4 | 8 | 5.81 | .342 | .390 | 1.61 | 10.7 | 3.8 | 6.0 | 100 | 119 | 14 | 42 | 67 | 0 | 0 | 4 | 69 | 16 | C |
| SP | Zimmermann, B.Zimmermann, Bruce >> | 26 | 2021 | L | 16 | 4 | 5 | 5.04 | .324 | .370 | 1.52 | 10.5 | 3.1 | 7.9 | 64 | 75 | 14 | 22 | 56 | 0 | 0 | 0 | 82 | 18 | C |
| SP | Williams, T.Williams, Trevor >> | 29 | 2021 | R | 22 | 4 | 2 | 4.35 | .325 | .370 | 1.49 | 10.4 | 3.1 | 8.9 | 91 | 105 | 11 | 31 | 90 | 0 | 0 | 0 | 71 | 19 | C |
| SP | Lynch, D.Lynch, Daniel >> | 24 | 2021 | L | 10 | 4 | 6 | 5.69 | .342 | .390 | 1.63 | 10.6 | 4.1 | 7.3 | 68 | 80 | 9 | 31 | 55 | 0 | 0 | 4 | 81 | 17 | C |
| SP | Crowe, W.Crowe, Wil >> | 26 | 2021 | R | 21 | 4 | 8 | 5.48 | .338 | .380 | 1.58 | 9.8 | 4.4 | 8.6 | 116 | 126 | 25 | 57 | 111 | 0 | 0 | 3 | 80 | 19 | C |
| SP | Anderson, B.Anderson, Brett >> | 33 | 2021 | L | 28 | 4 | 9 | 4.22 | .304 | .350 | 1.35 | 9.6 | 2.6 | 5.4 | 96 | 102 | 11 | 28 | 58 | 0 | 0 | 0 | 72 | 15 | C |
| SP | Chi Gonzalez, C.Chi Gonzalez, Chi >> | 29 | 2021 | R | 10 | 3 | 7 | 6.46 | .331 | .380 | 1.53 | 11.3 | 2.5 | 5.0 | 101 | 127 | 18 | 28 | 56 | 0 | 0 | 2 | 76 | 15 | C |
| SP | Wilson, B.Wilson, Bryse >> | 23 | 2021 | R | 17 | 3 | 7 | 5.35 | .316 | .360 | 1.45 | 10.3 | 2.7 | 5.6 | 74 | 85 | 15 | 22 | 46 | 0 | 0 | 2 | 83 | 15 | C |
| SP | Lopez, J.Lopez, Jorge >> | 28 | 2021 | R | 12 | 3 | 14 | 6.07 | .347 | .390 | 1.64 | 10.6 | 4.2 | 8.3 | 121 | 142 | 21 | 56 | 112 | 0 | 0 | 9 | 66 | 18 | C |
| SP | Shoemaker, M.Shoemaker, Matt >> | 34 | 2021 | R | 4 | 3 | 8 | 8.06 | .345 | .400 | 1.67 | 11.0 | 4.1 | 6.0 | 60 | 73 | 15 | 27 | 40 | 0 | 0 | 1 | 68 | 16 | C |
| SP | Wells, A.Wells, Alexander >> | 24 | 2021 | L | 3 | 2 | 3 | 6.75 | .337 | .390 | 1.64 | 11.4 | 3.4 | 5.6 | 42 | 53 | 10 | 16 | 26 | 0 | 0 | 0 | 69 | 16 | C |
| SP | Anderson, C.Anderson, Chase >> | 33 | 2021 | R | 22 | 2 | 4 | 6.75 | .316 | .370 | 1.48 | 9.6 | 3.8 | 6.6 | 48 | 51 | 10 | 20 | 35 | 0 | 0 | 0 | 62 | 17 | C |
| SP | Arihara, K.Arihara, Kohei >> | 28 | 2021 | R | 18 | 2 | 4 | 6.64 | .309 | .360 | 1.45 | 10.1 | 2.9 | 5.4 | 40 | 45 | 11 | 13 | 24 | 0 | 0 | 1 | 72 | 16 | C |
| SP | Kranick, M.Kranick, Max >> | 23 | 2021 | R | 6 | 2 | 3 | 6.28 | .347 | .400 | 1.74 | 11.1 | 4.5 | 7.6 | 38 | 47 | 4 | 19 | 32 | 0 | 0 | 2 | 76 | 18 | C |
| SP | Allen, L.Allen, Logan >> | 24 | 2021 | L | 16 | 2 | 7 | 6.26 | .319 | .370 | 1.50 | 10.4 | 3.1 | 6.7 | 50 | 58 | 12 | 17 | 37 | 0 | 0 | 4 | 65 | 17 | C |
| SP | Barria, J.Barria, Jaime >> | 24 | 2021 | R | 8 | 2 | 4 | 4.61 | .333 | .380 | 1.59 | 11.3 | 3.1 | 5.6 | 56 | 70 | 8 | 19 | 35 | 0 | 0 | 0 | 77 | 15 | C |
| SP | Watkins, S.Watkins, Spenser >> | 28 | 2021 | R | 1 | 2 | 7 | 8.07 | .351 | .400 | 1.72 | 12.3 | 3.2 | 5.8 | 54 | 74 | 14 | 19 | 35 | 0 | 0 | 4 | 61 | 15 | C |
| SP | Akin, K.Akin, Keegan >> | 26 | 2021 | L | 14 | 2 | 10 | 6.63 | .337 | .380 | 1.58 | 10.4 | 3.8 | 7.8 | 95 | 110 | 17 | 40 | 82 | 0 | 0 | 5 | 71 | 18 | C |
| SP | Blackburn, P.Blackburn, Paul >> | 27 | 2021 | R | 4 | 1 | 4 | 5.87 | .333 | .390 | 1.63 | 12.3 | 2.4 | 6.2 | 38 | 52 | 8 | 10 | 26 | 0 | 0 | 1 | 76 | 16 | C |
| SP | De Jong, C.De Jong, Chase >> | 27 | 2021 | R | 15 | 1 | 4 | 5.77 | .329 | .380 | 1.58 | 10.3 | 4.0 | 8.2 | 43 | 49 | 11 | 19 | 39 | 0 | 0 | 0 | 85 | 19 | C |
| SP | Cahill, T.Cahill, Trevor >> | 33 | 2021 | R | 19 | 1 | 5 | 6.57 | .316 | .370 | 1.51 | 10.2 | 3.4 | 7.8 | 37 | 42 | 4 | 14 | 32 | 0 | 0 | 2 | 74 | 18 | C |
| SP | Dobnak, R.Dobnak, Randy >> | 26 | 2021 | R | 8 | 1 | 7 | 7.64 | .328 | .380 | 1.56 | 11.9 | 2.2 | 4.9 | 50 | 66 | 11 | 12 | 27 | 0 | 1 | 2 | 65 | 15 | C |
| SP | Garrett, B.Garrett, Braxton >> | 23 | 2021 | L | 7 | 1 | 2 | 5.03 | .356 | .420 | 1.82 | 11.1 | 5.3 | 8.5 | 34 | 42 | 3 | 20 | 32 | 0 | 0 | 4 | 76 | 20 | C |
| SP | Detmers, R.Detmers, Reid >> | 21 | 2021 | L | 5 | 1 | 3 | 7.40 | .346 | .420 | 1.85 | 11.7 | 5.0 | 8.6 | 20 | 26 | 5 | 11 | 19 | 0 | 0 | 1 | 72 | 19 | C |
| SP | Carrasco, C.Carrasco, Carlos >> | 34 | 2021 | R | 23 | 1 | 5 | 6.04 | .313 | .360 | 1.45 | 10.0 | 3.1 | 8.5 | 53 | 59 | 12 | 18 | 50 | 0 | 0 | 1 | 79 | 20 | C |
| SP | Mejia, H.Mejia, Humberto >> | 24 | 2021 | R | 2 | 0 | 3 | 7.25 | .350 | .420 | 1.86 | 13.1 | 3.7 | 8.2 | 22 | 32 | 5 | 9 | 20 | 0 | 0 | 0 | 79 | 20 | C |
| SP | Kowar, J.Kowar, Jackson >> | 24 | 2021 | R | 3 | 0 | 6 | 11.27 | .387 | .450 | 2.10 | 12.9 | 6.0 | 8.7 | 30 | 43 | 7 | 20 | 29 | 0 | 0 | 8 | 61 | 19 | C |
| SP | Barnes, C.Barnes, Charlie >> | 25 | 2021 | L | 7 | 0 | 3 | 5.92 | .333 | .390 | 1.63 | 10.9 | 3.8 | 4.7 | 38 | 46 | 4 | 16 | 20 | 0 | 0 | 0 | 76 | 15 | C |
| SP | Oviedo, J.Oviedo, Johan >> | 23 | 2021 | R | 23 | 0 | 5 | 4.91 | .333 | .380 | 1.58 | 8.9 | 5.4 | 7.4 | 62 | 61 | 8 | 37 | 51 | 0 | 0 | 2 | 79 | 18 | C |
| SP | Kremer, D.Kremer, Dean >> | 25 | 2021 | R | 11 | 0 | 7 | 7.55 | .342 | .390 | 1.66 | 10.7 | 4.2 | 8.0 | 53 | 63 | 17 | 25 | 47 | 0 | 0 | 5 | 73 | 19 | C |
| SP | Castano, D.Castano, Daniel >> | 26 | 2021 | L | 19 | 0 | 2 | 4.87 | .300 | .370 | 1.50 | 9.9 | 3.6 | 5.9 | 20 | 22 | 3 | 8 | 13 | 0 | 0 | 0 | 72 | 16 | C |
| SP | Otto, G.Otto, Glenn >> | 25 | 2021 | R | 12 | 0 | 3 | 9.26 | .336 | .410 | 1.74 | 12.5 | 3.1 | 11.0 | 23 | 32 | 2 | 8 | 28 | 0 | 0 | 1 | 69 | 24 | C |
| SP | Brault, S.Brault, Steven >> | 29 | 2021 | L | 6 | 0 | 3 | 5.86 | .331 | .400 | 1.67 | 11.0 | 4.0 | 6.3 | 27 | 33 | 3 | 12 | 19 | 0 | 0 | 0 | 70 | 16 | C |