| SP | Buehrle, M.Buehrle, Mark >> | 29 | 2008 | L | 21 | 15 | 12 | 3.79 | .305 | .340 | 1.34 | 9.9 | 2.1 | 5.8 | 218 | 240 | 22 | 52 | 140 | 1 | 0 | 4 | 105 | +4.43 | C |
| SP | Garland, J.Garland, Jon >> | 29 | 2008 | R | 2 | 14 | 8 | 4.90 | .331 | .370 | 1.51 | 10.9 | 2.7 | 4.1 | 196 | 237 | 23 | 59 | 90 | 1 | 0 | 4 | 108 | +0.78 | C |
| SP | Padilla, V.Padilla, Vicente >> | 31 | 2008 | R | 9 | 14 | 8 | 4.74 | .323 | .360 | 1.46 | 9.7 | 3.4 | 6.7 | 171 | 185 | 26 | 65 | 127 | 1 | 0 | 12 | 93 | +1.07 | C |
| SP | Jackson, E.Jackson, Edwin >> | 25 | 2008 | R | 6 | 14 | 11 | 4.42 | .331 | .370 | 1.51 | 9.8 | 3.8 | 5.3 | 183 | 199 | 23 | 77 | 108 | 0 | 0 | 7 | 87 | +2.34 | C |
| SP | Pettitte, A.Pettitte, Andy >> | 36 | 2008 | L | 11 | 14 | 14 | 4.54 | .316 | .350 | 1.41 | 10.3 | 2.4 | 7.0 | 204 | 233 | 19 | 55 | 158 | 0 | 0 | 6 | 110 | +2.17 | C |
| SP | Jurrjens, J.Jurrjens, Jair >> | 22 | 2008 | R | 25 | 13 | 10 | 3.68 | .310 | .350 | 1.37 | 9.0 | 3.4 | 6.7 | 188 | 188 | 11 | 70 | 139 | 0 | 0 | 3 | 109 | +2.18 | C |
| SP | Perkins, G.Perkins, Glen >> | 25 | 2008 | L | 3 | 12 | 4 | 4.41 | .324 | .360 | 1.47 | 10.9 | 2.3 | 4.4 | 151 | 183 | 25 | 39 | 74 | 0 | 0 | 2 | 87 | +1.33 | C |
| SP | Wolf, R.Wolf, Randy >> | 32 | 2008 | L | 26 | 12 | 12 | 4.30 | .311 | .350 | 1.38 | 9.0 | 3.4 | 7.7 | 190 | 191 | 21 | 71 | 162 | 1 | 0 | 3 | 88 | +0.97 | C |
| SP | Moehler, B.Moehler, Brian >> | 37 | 2008 | R | 18 | 11 | 8 | 4.56 | .305 | .340 | 1.35 | 10.0 | 2.2 | 4.9 | 150 | 166 | 20 | 36 | 82 | 0 | 0 | 3 | 69 | +1.21 | C |
| SP | Blackburn, N.Blackburn, Nick >> | 26 | 2008 | R | 13 | 11 | 11 | 4.05 | .309 | .350 | 1.36 | 10.4 | 1.8 | 4.5 | 193 | 224 | 23 | 39 | 96 | 0 | 0 | 2 | 93 | +2.32 | C |
| SP | Parra, M.Parra, Manny >> | 26 | 2008 | L | 8 | 10 | 8 | 4.39 | .335 | .370 | 1.54 | 9.8 | 4.1 | 8.0 | 166 | 181 | 18 | 75 | 147 | 0 | 0 | 17 | 89 | +0.44 | C |
| SP | Myers, B.Myers, Brett >> | 28 | 2008 | R | 23 | 10 | 13 | 4.55 | .311 | .350 | 1.38 | 9.3 | 3.1 | 7.7 | 190 | 197 | 29 | 65 | 163 | 2 | 0 | 2 | 109 | +0.66 | C |
| SP | Millwood, K.Millwood, Kevin >> | 34 | 2008 | R | 4 | 9 | 10 | 5.07 | .344 | .380 | 1.60 | 11.8 | 2.6 | 6.7 | 168 | 220 | 18 | 49 | 125 | 3 | 0 | 2 | 88 | +0.78 | C |
| SP | Eveland, D.Eveland, Dana >> | 25 | 2008 | L | 12 | 9 | 9 | 4.34 | .326 | .370 | 1.48 | 9.2 | 4.1 | 6.3 | 168 | 172 | 10 | 77 | 118 | 1 | 0 | 6 | 92 | +1.3 | C |
| SP | Cueto, J.Cueto, Johnny >> | 22 | 2008 | R | 20 | 9 | 14 | 4.81 | .316 | .360 | 1.41 | 9.2 | 3.5 | 8.2 | 174 | 178 | 29 | 68 | 158 | 0 | 0 | 6 | 92 | +1.39 | C |
| SP | Johnson, J.Johnson, Josh >> | 24 | 2008 | R | 28 | 7 | 1 | 3.61 | .303 | .350 | 1.36 | 9.4 | 2.8 | 8.0 | 87 | 91 | 7 | 27 | 77 | 1 | 0 | 4 | 107 | +1.97 | C |
| SP | Perez, O.Perez, Odalis >> | 31 | 2008 | L | 7 | 7 | 12 | 4.34 | .327 | .370 | 1.49 | 10.3 | 3.1 | 6.7 | 159 | 182 | 22 | 55 | 119 | 0 | 0 | 5 | 88 | +1.46 | C |
| SP | Harang, A.Harang, Aaron >> | 30 | 2008 | R | 15 | 6 | 17 | 4.78 | .312 | .350 | 1.39 | 10.0 | 2.4 | 7.5 | 184 | 205 | 35 | 50 | 153 | 1 | 0 | 2 | 110 | +1.79 | C |