| SP | Gumbert, A.Gumbert, Ad >> | 25 | 1893 | R | 2 | 11 | 7 | 5.15 | .365 | .430 | 1.76 | 11.5 | 4.3 | 2.2 | 162 | 207 | 5 | 78 | 40 | 16 | 0 | 3 | 129 | +0.68 | C |
| SP | Zito, B.Zito, Barry >> | 30 | 2008 | L | 10 | 10 | 17 | 5.15 | .344 | .410 | 1.60 | 9.3 | 5.1 | 6.0 | 180 | 186 | 16 | 102 | 120 | 0 | 0 | 3 | 100 | -0.13 | C |
| SP | Vargas, C.Vargas, Claudio >> | 27 | 2005 | R | 11 | 9 | 9 | 5.24 | .322 | .390 | 1.46 | 10.0 | 3.2 | 6.5 | 132 | 146 | 25 | 47 | 95 | 0 | 0 | 6 | 94 | +0.34 | C |
| SP | Robertson, R.Robertson, Rich >> | 29 | 1997 | L | 5 | 8 | 12 | 5.69 | .346 | .410 | 1.63 | 10.3 | 4.3 | 4.2 | 147 | 169 | 19 | 70 | 69 | 0 | 0 | 10 | 85 | -0.42 | C |
| SP | McCaskill, K.McCaskill, Kirk >> | 27 | 1988 | R | 12 | 8 | 6 | 4.31 | .325 | .390 | 1.48 | 9.6 | 3.8 | 6.0 | 146 | 155 | 9 | 61 | 98 | 4 | 0 | 13 | 112 | +0.8 | C |
| SP | Arrighetti, S.Arrighetti, Spencer >> | 24 | 2024 | R | 30 | 7 | 13 | 4.53 | .314 | .380 | 1.41 | 8.6 | 4.0 | 10.6 | 145 | 139 | 21 | 65 | 171 | 0 | 0 | 3 | 89 | +0.3 | C |
| SP | Morton, C.Morton, Carl >> | 28 | 1972 | R | 20 | 7 | 13 | 3.92 | .298 | .360 | 1.30 | 8.9 | 2.8 | 2.7 | 172 | 170 | 16 | 53 | 51 | 3 | 0 | 1 | 112 | +0.1 | C |
| SP | Padilla, V.Padilla, Vicente >> | 27 | 2004 | R | 19 | 7 | 7 | 4.53 | .304 | .370 | 1.35 | 9.3 | 2.8 | 6.4 | 115 | 119 | 16 | 36 | 82 | 0 | 0 | 2 | 102 | +0.76 | C |
| SP | Trachsel, S.Trachsel, Steve >> | 25 | 1995 | R | 9 | 7 | 13 | 5.15 | .338 | .400 | 1.56 | 9.8 | 4.3 | 6.6 | 160 | 174 | 25 | 76 | 117 | 2 | 0 | 2 | 95 | -1.11 | C |
| SP | Robertson, N.Robertson, Nate >> | 31 | 2008 | L | 3 | 7 | 11 | 6.35 | .353 | .420 | 1.67 | 11.7 | 3.3 | 5.8 | 168 | 218 | 26 | 62 | 108 | 0 | 0 | 5 | 93 | -0.84 | C |
| SP | Hamlin, L.Hamlin, Luke >> | 40 | 1944 | R | 17 | 6 | 12 | 3.74 | .294 | .360 | 1.27 | 9.7 | 1.8 | 2.7 | 190 | 204 | 13 | 38 | 58 | 9 | 0 | 4 | 115 | +0.67 | C |
| SP | Bullinger, J.Bullinger, Jim >> | 31 | 1996 | R | 6 | 6 | 10 | 6.54 | .348 | .410 | 1.64 | 10.0 | 4.7 | 6.3 | 129 | 144 | 15 | 68 | 90 | 1 | 1 | 7 | 63 | -2.37 | C |
| SP | Levrault, A.Levrault, Allen >> | 24 | 2001 | R | 8 | 6 | 10 | 6.06 | .339 | .400 | 1.58 | 10.1 | 4.1 | 5.5 | 130 | 146 | 27 | 59 | 80 | 1 | 0 | 2 | 73 | -1.09 | C |
| SP | Peavy, J.Peavy, Jake >> | 35 | 2016 | R | 15 | 5 | 9 | 5.54 | .318 | .380 | 1.44 | 10.2 | 2.7 | 7.8 | 118 | 134 | 18 | 36 | 102 | 0 | 0 | 4 | 69 | -1.03 | C |
| SP | Rogers, K.Rogers, Kenny >> | 37 | 2001 | L | 4 | 5 | 7 | 6.19 | .350 | .420 | 1.66 | 11.3 | 3.7 | 5.6 | 120 | 150 | 18 | 49 | 74 | 0 | 0 | 4 | 106 | +0.15 | C |
| SP | Jimenez, J.Jimenez, Jose >> | 26 | 1999 | R | 13 | 5 | 14 | 5.85 | .328 | .390 | 1.50 | 9.6 | 3.9 | 6.2 | 163 | 173 | 16 | 71 | 113 | 2 | 0 | 10 | 100 | -0.48 | C |
| SP | Arrieta, J.Arrieta, Jake >> | 26 | 2012 | R | 18 | 3 | 9 | 6.20 | .308 | .370 | 1.38 | 9.6 | 2.8 | 8.6 | 114 | 122 | 16 | 35 | 109 | 0 | 0 | 4 | 85 | -0.88 | C |