| SP | Happ, J.Happ, J.A. >> | 40 | 2021 | L | 15 | 10 | 8 | 5.79 | .331 | .390 | 1.52 | 10.7 | 3.0 | 7.0 | 152 | 180 | 30 | 51 | 118 | 0 | 0 | 4 | 89 | -1.48 | U |
| SP | Kluber, C.Kluber, Corey >> | 36 | 2022 | R | 42 | 10 | 10 | 4.34 | .284 | .340 | 1.21 | 9.8 | 1.2 | 7.6 | 164 | 178 | 20 | 21 | 139 | 0 | 0 | 2 | 94 | +0.6 | U |
| SP | Hill, R.Hill, Rich >> | 42 | 2022 | L | 35 | 8 | 7 | 4.27 | .298 | .350 | 1.31 | 9.1 | 2.7 | 7.9 | 124 | 125 | 15 | 37 | 109 | 0 | 0 | 0 | 85 | +0.9 | C |
| SP | Cueto, J.Cueto, Johnny >> | 36 | 2022 | R | 38 | 8 | 10 | 3.35 | .286 | .340 | 1.23 | 9.2 | 1.9 | 5.8 | 158 | 161 | 15 | 33 | 102 | 1 | 0 | 2 | 111 | +3.5 | U |
| SP | Cobb, A.Cobb, Alex >> | 34 | 2022 | R | 36 | 7 | 8 | 3.73 | .299 | .350 | 1.31 | 9.2 | 2.6 | 9.1 | 149 | 152 | 9 | 43 | 151 | 0 | 0 | 4 | 94 | +2.6 | C |
| SP | Smyly, D.Smyly, Drew >> | 33 | 2022 | L | 53 | 7 | 8 | 3.47 | .279 | .330 | 1.20 | 8.6 | 2.2 | 7.7 | 106 | 101 | 16 | 26 | 91 | 0 | 0 | 3 | 86 | +1.9 | U |
| SP | Richards, G.Richards, Garrett >> | 34 | 2021 | R | 10 | 7 | 8 | 4.87 | .346 | .400 | 1.63 | 10.6 | 4.0 | 7.5 | 136 | 160 | 19 | 61 | 113 | 0 | 3 | 7 | 60 | +0.12 | U |
| SP | Lester, J.Lester, Jon >> | 38 | 2021 | L | 10 | 7 | 6 | 4.71 | .333 | .390 | 1.53 | 10.2 | 3.6 | 5.6 | 141 | 160 | 25 | 56 | 87 | 0 | 0 | 0 | 89 | -0.58 | U |
| SP | Wilson, B.Wilson, Bryse >> | 24 | 2021 | R | 21 | 6 | 14 | 5.35 | .308 | .360 | 1.37 | 10.0 | 2.3 | 5.5 | 153 | 170 | 30 | 39 | 93 | 0 | 0 | 4 | 84 | +0.5 | U |
| SP | Mills, A.Mills, Alec >> | 30 | 2021 | R | 18 | 6 | 7 | 5.07 | .318 | .370 | 1.44 | 10.4 | 2.6 | 6.6 | 119 | 137 | 16 | 34 | 87 | 0 | 1 | 4 | 67 | -0.4 | U |
| SP | Odorizzi, J.Odorizzi, Jake >> | 32 | 2022 | R | 30 | 6 | 6 | 4.40 | .301 | .360 | 1.33 | 9.0 | 3.0 | 7.3 | 106 | 106 | 14 | 35 | 86 | 0 | 0 | 2 | 86 | -0.1 | C |
| SP | Arrieta, J.Arrieta, Jake >> | 36 | 2021 | R | 1 | 5 | 14 | 7.39 | .372 | .430 | 1.84 | 12.2 | 4.3 | 7.4 | 98 | 133 | 24 | 47 | 81 | 0 | 0 | 3 | 72 | -2.78 | U |
| SP | Winckowski, J.Winckowski, Josh >> | 24 | 2022 | R | 3 | 5 | 7 | 5.89 | .337 | .400 | 1.60 | 10.9 | 3.5 | 5.7 | 70 | 85 | 10 | 27 | 44 | 0 | 0 | 0 | 83 | -0.3 | C |
| SP | Kranick, M.Kranick, Max >> | 24 | 2021 | R | 2 | 4 | 6 | 6.28 | .365 | .420 | 1.80 | 11.6 | 4.6 | 7.1 | 76 | 98 | 8 | 39 | 60 | 0 | 0 | 4 | 74 | -0.3 | U |
| SP | Anderson, C.Anderson, Chase >> | 34 | 2021 | R | 16 | 4 | 8 | 6.75 | .329 | .390 | 1.52 | 9.8 | 3.8 | 6.5 | 96 | 105 | 20 | 41 | 69 | 0 | 0 | 0 | 60 | -0.38 | U |
| SP | Urena, J.Urena, Jose >> | 30 | 2021 | R | 5 | 4 | 8 | 5.81 | .342 | .400 | 1.61 | 10.7 | 3.8 | 6.0 | 100 | 119 | 14 | 42 | 67 | 0 | 0 | 4 | 69 | -0.5 | U |
| SP | Allen, L.Allen, Logan >> | 25 | 2021 | L | 22 | 4 | 14 | 6.26 | .309 | .360 | 1.38 | 9.9 | 2.5 | 6.7 | 105 | 116 | 24 | 29 | 78 | 0 | 0 | 8 | 69 | -0.4 | U |
| SP | Peralta, W.Peralta, Wily >> | 33 | 2021 | R | 23 | 4 | 5 | 3.07 | .315 | .370 | 1.43 | 8.8 | 4.1 | 5.2 | 93 | 91 | 12 | 42 | 54 | 0 | 0 | 1 | 85 | +1.92 | U |
| SP | Martinez, A.Martinez, Adrian >> | 25 | 2022 | R | 14 | 4 | 6 | 6.24 | .327 | .390 | 1.54 | 10.9 | 3.0 | 8.4 | 57 | 69 | 13 | 19 | 53 | 0 | 0 | 6 | 85 | -0.7 | C |
| SP | Logue, Z.Logue, Zach >> | 26 | 2022 | L | 7 | 3 | 8 | 6.79 | .327 | .390 | 1.54 | 10.7 | 3.2 | 6.6 | 57 | 68 | 13 | 20 | 42 | 0 | 0 | 0 | 73 | -1.1 | C |
| SP | Hutchison, D.Hutchison, Drew >> | 31 | 2022 | R | 17 | 3 | 9 | 4.53 | .324 | .380 | 1.49 | 9.8 | 3.6 | 5.8 | 105 | 114 | 15 | 42 | 68 | 0 | 0 | 3 | 68 | 0 | C |
| SP | Hill, G.Hill, Garrett >> | 26 | 2022 | R | 35 | 3 | 3 | 4.03 | .301 | .360 | 1.37 | 8.0 | 4.4 | 6.0 | 60 | 53 | 8 | 29 | 40 | 0 | 0 | 2 | 64 | +0.4 | C |
| SP | Liberatore, M.Liberatore, Matthew >> | 22 | 2022 | L | 4 | 2 | 2 | 5.97 | .349 | .420 | 1.76 | 11.1 | 4.8 | 7.4 | 34 | 42 | 5 | 18 | 28 | 0 | 0 | 5 | 68 | -0.5 | C |
| SP | Miley, W.Miley, Wade >> | 35 | 2022 | L | 58 | 2 | 2 | 3.16 | .271 | .340 | 1.22 | 7.5 | 3.4 | 6.8 | 37 | 31 | 3 | 14 | 28 | 0 | 0 | 1 | 74 | 0 | C |
| SP | Pineda, M.Pineda, Michael >> | 33 | 2022 | R | 11 | 2 | 7 | 5.79 | .308 | .370 | 1.43 | 11.3 | 1.6 | 5.1 | 46 | 58 | 13 | 8 | 26 | 0 | 0 | 0 | 75 | -0.6 | C |
| SP | Bello, B.Bello, Brayan >> | 23 | 2022 | R | 5 | 2 | 8 | 4.71 | .360 | .420 | 1.79 | 11.8 | 4.3 | 8.7 | 57 | 75 | 1 | 27 | 55 | 1 | 0 | 2 | 79 | +0.4 | C |
| SP | Oller, A.Oller, Adam >> | 27 | 2022 | R | 6 | 2 | 8 | 6.30 | .343 | .400 | 1.64 | 10.0 | 4.7 | 5.6 | 74 | 82 | 17 | 39 | 46 | 0 | 0 | 4 | 70 | -1 | C |
| SP | Davidson, T.Davidson, Tucker >> | 26 | 2022 | L | 9 | 2 | 7 | 6.75 | .349 | .410 | 1.71 | 9.3 | 6.1 | 5.7 | 52 | 54 | 7 | 35 | 33 | 0 | 0 | 1 | 78 | -0.8 | C |
| SP | Jefferies, D.Jefferies, Daulton >> | 26 | 2022 | R | 19 | 1 | 7 | 5.72 | .298 | .360 | 1.38 | 10.6 | 1.8 | 6.5 | 39 | 46 | 4 | 8 | 28 | 0 | 0 | 3 | 87 | -0.2 | C |