| SP | Rogers, K.Rogers, Kenny >> | 40 | 2004 | L | 2 | 18 | 9 | 4.76 | .328 | .360 | 1.49 | 10.6 | 2.8 | 5.4 | 211 | 248 | 24 | 66 | 126 | 2 | 0 | 2 | 106 | 15 | S |
| SP | Colon, B.Colon, Bartolo >> | 31 | 2004 | R | 28 | 18 | 12 | 5.01 | .311 | .350 | 1.38 | 9.3 | 3.1 | 6.8 | 208 | 215 | 38 | 71 | 158 | 0 | 0 | 1 | 108 | 16 | U |
| SP | Mulder, M.Mulder, Mark >> | 27 | 2004 | L | 33 | 17 | 8 | 4.43 | .309 | .340 | 1.36 | 8.9 | 3.3 | 5.6 | 225 | 223 | 25 | 83 | 140 | 5 | 0 | 10 | 120 | 15 | A |
| SP | Buehrle, M.Buehrle, Mark >> | 25 | 2004 | L | 43 | 16 | 10 | 3.89 | .292 | .330 | 1.26 | 9.4 | 1.9 | 6.1 | 245 | 257 | 33 | 51 | 165 | 4 | 0 | 0 | 123 | 16 | S |
| SP | Suppan, J.Suppan, Jeff >> | 29 | 2004 | R | 27 | 16 | 9 | 4.16 | .309 | .340 | 1.37 | 9.2 | 3.1 | 5.3 | 188 | 192 | 25 | 65 | 110 | 0 | 0 | 4 | 107 | 15 | U |
| SP | Marquis, J.Marquis, Jason >> | 26 | 2004 | R | 8 | 15 | 7 | 3.71 | .317 | .350 | 1.42 | 9.6 | 3.1 | 6.2 | 201 | 215 | 26 | 70 | 138 | 0 | 0 | 6 | 111 | 16 | F |
| SP | Lawrence, B.Lawrence, Brian >> | 28 | 2004 | R | 10 | 15 | 14 | 4.12 | .312 | .350 | 1.38 | 10.0 | 2.4 | 5.4 | 203 | 226 | 26 | 55 | 121 | 2 | 0 | 2 | 106 | 15 | F |
| SP | Morris, M.Morris, Matt >> | 30 | 2004 | R | 39 | 15 | 10 | 4.72 | .298 | .330 | 1.29 | 9.1 | 2.5 | 5.8 | 202 | 205 | 35 | 56 | 131 | 3 | 0 | 3 | 111 | 15 | U |
| SP | Lee, C.Lee, Cliff >> | 26 | 2004 | L | 12 | 14 | 8 | 5.43 | .330 | .360 | 1.50 | 9.5 | 4.1 | 8.1 | 179 | 188 | 30 | 81 | 161 | 0 | 0 | 6 | 96 | 18 | A |
| SP | Drese, R.Drese, Ryan >> | 28 | 2004 | R | 3 | 14 | 10 | 4.20 | .316 | .350 | 1.41 | 10.1 | 2.5 | 4.3 | 207 | 233 | 16 | 58 | 98 | 2 | 0 | 1 | 108 | 14 | A |
| SP | Thomson, J.Thomson, John >> | 31 | 2004 | R | 31 | 14 | 8 | 3.72 | .303 | .340 | 1.32 | 9.5 | 2.4 | 6.0 | 198 | 210 | 20 | 52 | 133 | 0 | 0 | 3 | 106 | 16 | F |
| SP | Lieber, J.Lieber, Jon >> | 34 | 2004 | R | 19 | 14 | 8 | 4.33 | .303 | .340 | 1.33 | 11.0 | 0.9 | 5.2 | 176 | 216 | 20 | 18 | 102 | 0 | 0 | 7 | 115 | 15 | A |
| SP | Lackey, J.Lackey, John >> | 26 | 2004 | R | 15 | 14 | 13 | 4.67 | .313 | .350 | 1.39 | 9.8 | 2.7 | 6.5 | 198 | 215 | 22 | 60 | 144 | 1 | 0 | 11 | 106 | 16 | F |
| SP | Lima, J.Lima, Jose >> | 32 | 2004 | R | 44 | 13 | 5 | 4.07 | .290 | .320 | 1.25 | 9.4 | 1.8 | 4.9 | 170 | 178 | 33 | 34 | 93 | 0 | 0 | 3 | 84 | 15 | U |
| SP | Mussina, M.Mussina, Mike >> | 36 | 2004 | R | 29 | 12 | 9 | 4.59 | .303 | .340 | 1.33 | 9.8 | 2.2 | 7.2 | 164 | 178 | 22 | 40 | 132 | 1 | 0 | 5 | 107 | 17 | A |
| SP | Robertson, N.Robertson, Nate >> | 27 | 2004 | L | 14 | 12 | 10 | 4.90 | .316 | .350 | 1.41 | 9.6 | 3.0 | 7.1 | 196 | 210 | 30 | 66 | 155 | 1 | 1 | 5 | 102 | 17 | A |
| SP | Garland, J.Garland, Jon >> | 25 | 2004 | R | 23 | 12 | 11 | 4.89 | .311 | .350 | 1.38 | 9.2 | 3.2 | 4.7 | 217 | 223 | 34 | 76 | 113 | 1 | 0 | 3 | 112 | 14 | U |
| SP | Wakefield, T.Wakefield, Tim >> | 38 | 2004 | R | 18 | 12 | 10 | 4.87 | .312 | .350 | 1.38 | 9.4 | 3.0 | 5.6 | 188 | 197 | 29 | 63 | 116 | 0 | 0 | 9 | 104 | 15 | S |
| SP | Tomko, B.Tomko, Brett >> | 31 | 2004 | R | 32 | 11 | 7 | 4.04 | .305 | .340 | 1.34 | 9.1 | 3.0 | 5.0 | 194 | 196 | 19 | 64 | 108 | 2 | 0 | 10 | 107 | 15 | F |
| SP | Washburn, J.Washburn, Jarrod >> | 30 | 2004 | L | 24 | 11 | 8 | 4.64 | .303 | .340 | 1.34 | 9.6 | 2.4 | 5.2 | 149 | 159 | 20 | 40 | 86 | 1 | 0 | 5 | 105 | 15 | F |
| SP | Maroth, M.Maroth, Mike >> | 27 | 2004 | L | 4 | 11 | 13 | 4.31 | .314 | .350 | 1.40 | 10.1 | 2.4 | 4.5 | 217 | 244 | 25 | 59 | 108 | 2 | 0 | 10 | 116 | 14 | A |
| SP | Zito, B.Zito, Barry >> | 26 | 2004 | L | 25 | 11 | 11 | 4.48 | .314 | .350 | 1.39 | 9.1 | 3.4 | 6.9 | 213 | 216 | 28 | 81 | 163 | 0 | 0 | 4 | 110 | 17 | S |
| SP | Williams, W.Williams, Woody >> | 38 | 2004 | R | 36 | 11 | 8 | 4.18 | .303 | .340 | 1.33 | 9.2 | 2.8 | 6.2 | 189 | 193 | 20 | 58 | 131 | 0 | 0 | 12 | 108 | 16 | U |
| SP | Wilson, P.Wilson, Paul >> | 31 | 2004 | R | 16 | 11 | 6 | 4.36 | .313 | .350 | 1.39 | 9.4 | 3.1 | 5.8 | 183 | 192 | 26 | 63 | 117 | 1 | 0 | 7 | 111 | 15 | F |
| SP | Harang, A.Harang, Aaron >> | 26 | 2004 | R | 6 | 10 | 9 | 4.86 | .318 | .350 | 1.43 | 9.9 | 3.0 | 7.0 | 161 | 177 | 26 | 53 | 125 | 1 | 0 | 7 | 102 | 17 | F |
| SP | Willis, D.Willis, Dontrelle >> | 22 | 2004 | L | 20 | 10 | 11 | 4.02 | .311 | .350 | 1.38 | 9.6 | 2.8 | 6.4 | 197 | 210 | 20 | 61 | 139 | 2 | 0 | 2 | 109 | 16 | A |
| SP | Kennedy, J.Kennedy, Joe >> | 25 | 2004 | L | 22 | 9 | 7 | 3.66 | .317 | .350 | 1.42 | 9.1 | 3.7 | 6.5 | 162 | 163 | 17 | 67 | 117 | 1 | 0 | 5 | 106 | 16 | F |
| SP | Millwood, K.Millwood, Kevin >> | 30 | 2004 | R | 7 | 9 | 6 | 4.85 | .322 | .360 | 1.46 | 9.9 | 3.3 | 8.0 | 141 | 155 | 14 | 51 | 125 | 0 | 0 | 4 | 100 | 18 | F |
| SP | Moyer, J.Moyer, Jamie >> | 42 | 2004 | L | 11 | 7 | 13 | 5.21 | .313 | .350 | 1.39 | 9.7 | 2.8 | 5.6 | 202 | 217 | 44 | 63 | 125 | 1 | 0 | 1 | 105 | 15 | S |
| SP | Pineiro, J.Pineiro, Joel >> | 26 | 2004 | R | 35 | 6 | 11 | 4.67 | .303 | .340 | 1.34 | 9.3 | 2.8 | 7.1 | 140 | 144 | 21 | 43 | 111 | 1 | 0 | 4 | 117 | 17 | U |