| RP | Whitlock, G.Whitlock, Garrett >> | 25 | 2021 | R | 75 | 8 | 4 | 1.96 | .261 | .300 | 1.11 | 7.9 | 2.1 | 10.0 | 73 | 64 | 6 | 17 | 81 | 0 | 2 | 3 | 31 | 20 | C |
| RP | Ottavino, A.Ottavino, Adam >> | 35 | 2021 | R | 46 | 7 | 3 | 4.21 | .315 | .350 | 1.45 | 8.0 | 5.1 | 10.3 | 62 | 55 | 5 | 35 | 71 | 0 | 11 | 4 | 23 | 21 | C |
| RP | Perez, M.Perez, Martin >> | 30 | 2021 | L | 19 | 7 | 8 | 4.74 | .328 | .360 | 1.51 | 10.7 | 2.8 | 7.7 | 114 | 136 | 19 | 36 | 97 | 0 | 0 | 2 | 58 | 18 | C |
| RP | Barnes, M.Barnes, Matt >> | 31 | 2021 | R | 85 | 6 | 5 | 3.79 | .262 | .300 | 1.13 | 6.8 | 3.3 | 14.0 | 54 | 41 | 8 | 20 | 84 | 0 | 24 | 3 | 23 | 24 | C |
| RP | Sawamura, H.Sawamura, Hirokazu >> | 33 | 2021 | R | 49 | 5 | 1 | 3.06 | .313 | .350 | 1.45 | 7.6 | 5.4 | 10.4 | 53 | 45 | 9 | 32 | 61 | 0 | 0 | 8 | 23 | 22 | C |
| RP | Robles, H.Robles, Hansel >> | 30 | 2021 | R | 56 | 3 | 5 | 4.43 | .304 | .340 | 1.38 | 7.6 | 4.8 | 9.9 | 69 | 58 | 8 | 37 | 76 | 0 | 14 | 4 | 23 | 20 | C |
| RP | Andriese, M.Andriese, Matt >> | 31 | 2021 | R | 12 | 2 | 3 | 5.21 | .336 | .380 | 1.63 | 12.2 | 2.4 | 9.4 | 48 | 65 | 7 | 13 | 50 | 0 | 1 | 0 | 28 | 20 | C |
| RP | Valdez, P.Valdez, Phillips >> | 29 | 2021 | R | 51 | 2 | 0 | 5.85 | .293 | .340 | 1.35 | 7.9 | 4.3 | 7.9 | 40 | 35 | 4 | 19 | 35 | 0 | 1 | 5 | 28 | 18 | C |
| RP | Hernandez, D.Hernandez, Darwinzon >> | 24 | 2021 | L | 55 | 2 | 2 | 3.38 | .316 | .360 | 1.50 | 6.5 | 7.0 | 12.2 | 40 | 29 | 5 | 31 | 54 | 0 | 0 | 3 | 23 | 23 | C |
| RP | Davis, A.Davis, Austin >> | 28 | 2021 | L | 48 | 1 | 2 | 5.13 | .290 | .340 | 1.38 | 8.3 | 4.2 | 9.7 | 26 | 24 | 4 | 12 | 28 | 0 | 0 | 1 | 23 | 24 | C |
| RP | Workman, B.Workman, Brandon >> | 32 | 2021 | R | 5 | 1 | 2 | 5.46 | .377 | .430 | 2.04 | 11.6 | 6.8 | 8.0 | 28 | 36 | 4 | 21 | 25 | 0 | 0 | 1 | 23 | 18 | C |
| RP | Taylor, J.Taylor, Josh >> | 28 | 2021 | L | 44 | 1 | 0 | 3.40 | .311 | .350 | 1.45 | 8.6 | 4.4 | 11.5 | 47 | 45 | 2 | 23 | 60 | 0 | 1 | 2 | 23 | 22 | C |
| RP | Feliz, M.Feliz, Michael >> | 28 | 2021 | R | 15 | 0 | 0 | 7.32 | .316 | .380 | 1.63 | 11.8 | 2.8 | 10.4 | 19 | 25 | 4 | 6 | 22 | 0 | 1 | 2 | 23 | 21 | C |