| SP | Buehler, W.Buehler, Walker >> | 26 | 2021 | R | 90 | 16 | 4 | 2.47 | .242 | .280 | 0.97 | 6.5 | 2.3 | 9.2 | 207 | 149 | 19 | 52 | 212 | 0 | 0 | 5 | 111 | 19 | C |
| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 100 | 15 | 4 | 2.46 | .221 | .260 | 0.87 | 6.0 | 1.8 | 11.9 | 179 | 119 | 23 | 36 | 236 | 1 | 0 | 2 | 105 | 22 | C |
| SP | Kershaw, C.Kershaw, Clayton >> | 33 | 2021 | L | 84 | 10 | 8 | 3.55 | .249 | .290 | 1.02 | 7.7 | 1.6 | 10.7 | 121 | 103 | 15 | 21 | 144 | 0 | 0 | 7 | 98 | 21 | C |
| SP | Bauer, T.Bauer, Trevor >> | 30 | 2021 | R | 94 | 8 | 5 | 2.59 | .246 | .290 | 1.01 | 6.0 | 3.1 | 11.5 | 107 | 71 | 19 | 37 | 137 | 1 | 0 | 3 | 111 | 22 | C |
| SP | Straily, D.Straily, Dan >> | 36 | 2019 | R | 3 | 8 | 16 | 9.82 | .423 | .460 | 2.23 | 15.2 | 4.9 | 5.9 | 188 | 317 | 22 | 103 | 123 | 0 | 0 | 12 | 56 | 12 | C |
| SP | Jackson, E.Jackson, Edwin >> | 42 | 2019 | R | 2 | 6 | 20 | 9.58 | .437 | .480 | 2.39 | 16.1 | 5.4 | 5.4 | 134 | 240 | 23 | 80 | 81 | 0 | 0 | 12 | 53 | 11 | C |
| SP | Brooks, A.Brooks, Aaron >> | 35 | 2019 | R | 22 | 6 | 8 | 5.65 | .328 | .370 | 1.51 | 10.0 | 3.6 | 5.1 | 110 | 122 | 21 | 44 | 62 | 0 | 0 | 4 | 63 | 13 | C |
| SP | Buchholz, C.Buchholz, Clay >> | 41 | 2019 | R | 7 | 4 | 10 | 6.56 | .368 | .410 | 1.80 | 12.9 | 3.3 | 4.5 | 118 | 169 | 13 | 43 | 59 | 0 | 0 | 2 | 79 | 10 | C |
| SP | Richard, C.Richard, Clayton >> | 42 | 2019 | L | 9 | 4 | 20 | 5.96 | .365 | .400 | 1.76 | 11.7 | 4.1 | 2.9 | 180 | 234 | 9 | 82 | 58 | 0 | 0 | 12 | 70 | 8 | C |
| SP | Gonsolin, T.Gonsolin, Tony >> | 27 | 2021 | R | 59 | 4 | 1 | 3.23 | .300 | .350 | 1.36 | 6.7 | 5.6 | 10.6 | 55 | 41 | 8 | 34 | 65 | 0 | 0 | 4 | 66 | 20 | C |
| SP | Eshelman, T.Eshelman, Tom >> | 31 | 2019 | R | 33 | 4 | 8 | 6.50 | .301 | .340 | 1.32 | 10.3 | 1.6 | 6.0 | 165 | 188 | 12 | 29 | 110 | 0 | 0 | 0 | 79 | 19 | C |
| SP | Chacin, J.Chacin, Jhoulys >> | 37 | 2019 | R | 6 | 3 | 12 | 6.01 | .391 | .430 | 1.99 | 12.8 | 5.1 | 6.4 | 103 | 147 | 25 | 58 | 73 | 0 | 0 | 3 | 63 | 14 | C |
| SP | Shepherd, C.Shepherd, Chandler >> | 32 | 2019 | R | 38 | 0 | 0 | 6.63 | .304 | .340 | 1.34 | 9.9 | 2.2 | 8.0 | 168 | 184 | 5 | 41 | 149 | 0 | 0 | 16 | 76 | 21 | C |