| SP | Johnson, W.Johnson, Walter | 21 | Tigers | R | 107.0 | 17 | 17 | 12 | 3 | 1.98 | .275 | 1.13 | 7.7 | 2.5 | 4.5 | 127.1 | 109 | 55 | 28 | 3 | 35 | 63 | 4 | 0 | 0 | 2 | 15 | 1 | 7 | 3.17 |
| SP | Lincecum, T.Lincecum, Tim | 24 | Rangers | R | 79.0 | 16 | 16 | 9 | 3 | 2.66 | .269 | 1.10 | 6.7 | 3.2 | 8.6 | 105.0 | 78 | 39 | 31 | 7 | 37 | 100 | 3 | 0 | 0 | 2 | 12 | 1 | 5 | 3.05 |
| SP | Kershaw, C.Kershaw, Clayton | 21 | Mets | L | 68.0 | 18 | 18 | 8 | 5 | 2.53 | .236 | 0.92 | 4.7 | 3.6 | 7.9 | 110.1 | 57 | 33 | 31 | 4 | 44 | 96 | 0 | 0 | 0 | 0 | 14 | 1 | 5 | 2.95 |
| SP | Valenzuela, F.Valenzuela, Fernando | 21 | Padres | L | 61.0 | 19 | 19 | 8 | 5 | 3.53 | .285 | 1.19 | 8.1 | 2.7 | 5.0 | 132.2 | 119 | 57 | 52 | 6 | 39 | 74 | 3 | 0 | 0 | 1 | 12 | 1 | 4 | 3.38 |
| SP | Drysdale, D.Drysdale, Don | 21 | Padres | R | 59.0 | 17 | 17 | 7 | 3 | 3.01 | .262 | 1.04 | 6.7 | 2.7 | 5.2 | 116.2 | 86 | 43 | 39 | 8 | 35 | 67 | 0 | 0 | 0 | 0 | 14 | 3 | 2 | 3.72 |
| SP | Bradley, G.Bradley, George | 24 | Astros | R | 55.0 | 19 | 19 | 8 | 5 | 3.84 | .294 | 1.23 | 8.9 | 2.2 | 4.1 | 126.2 | 125 | 55 | 54 | 4 | 31 | 57 | 5 | 0 | 0 | 0 | 12 | 2 | 8 | 3.29 |