| SP | Martinez, P.Martinez, Pedro | 32 | Cowboys🤠 | R | 177.0 | 26 | 26 | 18 | 6 | 2.63 | .241 | 0.90 | 6.6 | 1.5 | 9.3 | 215.2 | 158 | 64 | 63 | 21 | 37 | 223 | 20 | 0 | 0 | 5 | 18 | 10 | 3 | 2.85 |
| SP | Santana, J.Santana, Johan | 30 | Tycoons💰 | L | 148.0 | 27 | 27 | 16 | 4 | 2.85 | .265 | 1.07 | 7.1 | 2.6 | 7.6 | 215.0 | 169 | 68 | 68 | 22 | 61 | 181 | 7 | 0 | 0 | 3 | 19 | 3 | 5 | 3.54 |
| SP | Gooden, D.Gooden, Dwight # | 31 | Rockets🚀 | R | 131.0 | 26 | 26 | 15 | 7 | 3.19 | .268 | 1.08 | 7.4 | 2.4 | 6.3 | 205.2 | 168 | 75 | 73 | 23 | 54 | 144 | 15 | 0 | 0 | 3 | 16 | 4 | 2 | 3.90 |
| SP | Scherzer, M.Scherzer, Max | 30 | Rockets🚀 | R | 93.0 | 26 | 26 | 14 | 6 | 4.28 | .304 | 1.28 | 8.5 | 3.0 | 9.0 | 189.1 | 179 | 90 | 90 | 31 | 64 | 188 | 4 | 0 | 0 | 1 | 13 | 5 | 6 | 4.24 |
| SP | Hunter, C.Hunter, Catfish | 29 | Rockets🚀 | R | 88.0 | 25 | 25 | 11 | 9 | 3.21 | .253 | 1.02 | 6.7 | 2.5 | 3.9 | 187.2 | 140 | 80 | 67 | 33 | 51 | 80 | 7 | 0 | 0 | 2 | 15 | 0 | 1 | 5.26 |
| SP | Antonelli, J.Antonelli, Johnny | 28 | Buckeyes🌰 | L | 81.0 | 25 | 25 | 12 | 7 | 4.03 | .282 | 1.16 | 7.5 | 2.9 | 5.2 | 192.0 | 161 | 90 | 86 | 35 | 61 | 110 | 5 | 0 | 0 | 1 | 12 | 4 | 2 | 5.24 |