| SP | Hernandez, F.Hernandez, Felix # | 29 | Red Sox | R | 100 | 38 | 38 | 26 | 8 | 3.26 | .261 | 1.05 | 7.6 | 1.9 | 7.7 | 303.1 | 255 | 117 | 110 | 37 | 63 | 258 | 19 | 0 | 0 | 5 | 22 | 3 | 1 | 3.54 |
| SP | Porcello, R.Porcello, Rick | 26 | Astros | R | 90 | 34 | 34 | 20 | 10 | 2.99 | .252 | 1.01 | 6.7 | 2.4 | 5.7 | 268.0 | 200 | 95 | 89 | 30 | 70 | 170 | 13 | 0 | 0 | 2 | 23 | 1 | 4 | 3.98 |
| RP | Gonzalez, E.Gonzalez, Edgar | 32 | Red Sox | R | 86 | 63 | 0 | 13 | 5 | 2.97 | .258 | 1.04 | 7.1 | 2.3 | 6.6 | 139.1 | 109 | 47 | 46 | 13 | 36 | 102 | 0 | 5 | 3 | 0 | 0 | 0 | 0 | 3.53 |
| RP | Tazawa, J.Tazawa, Junichi | 29 | Mariners | R | 85 | 77 | 0 | 10 | 7 | 3.88 | .288 | 1.20 | 8.4 | 2.5 | 7.1 | 111.1 | 103 | 49 | 48 | 18 | 31 | 88 | 0 | 19 | 4 | 0 | 0 | 1 | 0 | 4.39 |