| SP | Scherzer, M.Scherzer, Max | 23 | Senators | R | 91 | 32 | 32 | 17 | 8 | 3.15 | .266 | 1.08 | 7.2 | 2.6 | 8.4 | 239.2 | 190 | 93 | 84 | 29 | 68 | 223 | 7 | 0 | 0 | 3 | 23 | 3 | 5 | 3.60 |
| SP | Lincecum, T.Lincecum, Tim | 21 | Tigers | R | 68 | 32 | 32 | 20 | 6 | 4.34 | .301 | 1.27 | 7.6 | 3.8 | 8.8 | 230.1 | 195 | 122 | 111 | 32 | 98 | 225 | 5 | 0 | 0 | 3 | 15 | 5 | 8 | 4.20 |
| SP | Hendrix, C.Hendrix, Claude | 33 | Tigers | R | 87 | 32 | 32 | 20 | 5 | 4.54 | .301 | 1.26 | 8.7 | 2.6 | 4.8 | 246.0 | 239 | 131 | 124 | 25 | 71 | 132 | 12 | 0 | 0 | 1 | 16 | 8 | 5 | 4.21 |
| CL | Chapman, A.Chapman, Aroldis | 23 | Reds | L | 97 | 68 | 0 | 3 | 9 | 4.41 | .280 | 1.15 | 7.0 | 3.4 | 9.4 | 69.1 | 54 | 35 | 34 | 10 | 26 | 72 | 0 | 51 | 5 | 0 | 0 | 1 | 3 | 3.97 |
| CL | Kimbrel, C.Kimbrel, Craig | 22 | Pirates | R | 100 | 54 | 0 | 6 | 7 | 2.22 | .201 | 0.75 | 4.4 | 2.4 | 9.8 | 65.0 | 32 | 16 | 16 | 5 | 17 | 71 | 0 | 32 | 3 | 0 | 0 | 0 | 2 | 2.60 |