| SP | McKenzie, T.McKenzie, Triston | 27 | Guardians | R | 97 | 32 | 32 | 20 | 8 | 3.99 | .284 | 1.16 | 8.4 | 2.0 | 9.4 | 243.1 | 228 | 111 | 108 | 32 | 55 | 254 | 7 | 0 | 0 | 2 | 14 | 6 | 6 | 3.37 |
| SP | Murphy, T.Murphy, Tom-LAA # + | 26 | Angels | R | 95 | 31 | 31 | 18 | 9 | 2.90 | .255 | 1.00 | 6.7 | 2.3 | 6.3 | 242.1 | 181 | 81 | 78 | 31 | 62 | 170 | 11 | 0 | 0 | 2 | 24 | 6 | 2 | 4.10 |
| SP | Downing, A.Downing, Al-NYY + | 25 | Yankees | L | 91 | 30 | 30 | 18 | 5 | 3.39 | .274 | 1.10 | 6.8 | 3.1 | 8.0 | 225.2 | 171 | 85 | 85 | 29 | 78 | 199 | 7 | 0 | 0 | 3 | 18 | 6 | 2 | 4.03 |
| SP | Liriano, F.Liriano, Francisco-MIN + | 26 | Twins | L | 100 | 31 | 31 | 17 | 5 | 3.73 | .261 | 1.04 | 7.6 | 1.7 | 10.3 | 222.0 | 188 | 92 | 92 | 33 | 43 | 255 | 6 | 0 | 0 | 1 | 17 | 4 | 8 | 3.27 |
| CL | Wagner, B.Wagner, Billy-HOU + | 28 | Astros | L | 100 | 52 | 0 | 5 | 5 | 1.76 | .228 | 0.84 | 5.0 | 2.6 | 9.7 | 66.2 | 37 | 14 | 13 | 6 | 19 | 71 | 0 | 34 | 3 | 0 | 0 | 3 | 2 | 3.03 |
| CL | Betances, D.Betances, Dellin-NYY + | 29 | Yankees | R | 99 | 54 | 0 | 2 | 4 | 2.79 | .221 | 0.83 | 4.6 | 3.0 | 10.8 | 51.2 | 26 | 16 | 16 | 7 | 17 | 61 | 0 | 46 | 6 | 0 | 0 | 1 | 0 | 3.45 |
| CL | Bautista, F.Bautista, Félix | 30 | Orioles | R | 93 | 52 | 0 | 3 | 9 | 3.13 | .299 | 1.26 | 7.3 | 4.2 | 10.3 | 54.2 | 44 | 21 | 19 | 4 | 25 | 62 | 0 | 31 | 5 | 0 | 0 | 1 | 1 | 3.11 |