| SP | Martinez, P.Martinez, Pedro | 29 | Knights | R | 86.0 | 14 | 14 | 10 | 2 | 2.63 | .241 | 0.94 | 6.5 | 1.9 | 9.3 | 102.2 | 74 | 33 | 30 | 11 | 22 | 105 | 4 | 0 | 0 | 2 | 10 | 2 | 2 | 3.05 |
| SP | Halladay, R.Halladay, Roy | 28 | Knights | R | 85.0 | 14 | 14 | 11 | 1 | 3.14 | .292 | 1.24 | 9.1 | 2.1 | 5.9 | 103.1 | 104 | 37 | 36 | 10 | 24 | 68 | 4 | 0 | 0 | 2 | 11 | 0 | 0 | 3.64 |
| SP | Duchscherer, J.Duchscherer, Justin | 31 | Hvit Hus | R | 78.0 | 14 | 14 | 11 | 1 | 3.29 | .249 | 0.99 | 7.0 | 2.0 | 3.7 | 101.1 | 78 | 37 | 37 | 11 | 22 | 42 | 2 | 0 | 0 | 1 | 11 | 1 | 1 | 4.27 |
| SP | Schmidt, J.Schmidt, Jason # | 30 | Tigers | R | 64.0 | 14 | 14 | 7 | 2 | 3.26 | .290 | 1.22 | 7.9 | 3.1 | 10.3 | 107.2 | 94 | 40 | 39 | 11 | 37 | 123 | 2 | 0 | 0 | 1 | 10 | 1 | 4 | 3.10 |
| SP | Vazquez, J.Vazquez, Javier # | 33 | Big Red One's | R | 51.0 | 14 | 14 | 6 | 2 | 3.38 | .280 | 1.16 | 7.6 | 2.8 | 8.6 | 93.1 | 79 | 36 | 35 | 12 | 29 | 89 | 2 | 0 | 0 | 0 | 10 | 1 | 3 | 3.73 |
| SP | Weaver, J.Weaver, Jered # | 24 | Snakes | R | 49.0 | 14 | 14 | 6 | 5 | 3.15 | .299 | 1.23 | 8.1 | 3.0 | 6.2 | 100.0 | 90 | 38 | 35 | 16 | 33 | 69 | 2 | 0 | 0 | 2 | 9 | 5 | 0 | 4.84 |
| SP | Lincecum, T.Lincecum, Tim | 25 | Sharks | R | 44.0 | 14 | 14 | 7 | 6 | 3.84 | .312 | 1.34 | 8.1 | 4.0 | 9.5 | 98.1 | 88 | 42 | 42 | 11 | 44 | 103 | 1 | 0 | 0 | 0 | 9 | 2 | 8 | 3.77 |