| SP | Halladay, R.Halladay, Roy | 28 | Destroyers | R | 86 | 32 | 32 | 17 | 8 | 2.97 | .268 | 1.07 | 7.8 | 1.8 | 6.2 | 236.2 | 205 | 81 | 78 | 24 | 48 | 163 | 12 | 0 | 0 | 2 | 23 | 7 | 3 | 3.64 |
| SP | Johnson, R.Johnson, Randy | 38 | Destroyers | L | 97 | 33 | 33 | 18 | 8 | 2.80 | .282 | 1.13 | 7.4 | 2.8 | 9.8 | 238.0 | 195 | 79 | 74 | 17 | 75 | 259 | 3 | 0 | 0 | 1 | 25 | 10 | 3 | 2.82 |
| SP | Santana, J.Santana, Johan | 25 | Metro | L | 100 | 33 | 33 | 14 | 16 | 3.90 | .298 | 1.24 | 7.8 | 3.3 | 8.8 | 226.0 | 197 | 101 | 98 | 34 | 84 | 221 | 1 | 0 | 0 | 1 | 22 | 7 | 4 | 4.21 |
| SP | Lincecum, T.Lincecum, Tim | 25 | Pointers | R | 92 | 33 | 33 | 17 | 13 | 4.24 | .291 | 1.22 | 7.9 | 3.1 | 9.3 | 223.0 | 195 | 110 | 105 | 23 | 76 | 230 | 2 | 0 | 0 | 0 | 20 | 4 | 7 | 3.35 |
| RP | Papelbon, J.Papelbon, Jonathan | 26 | Sharks | R | 93 | 86 | 0 | 6 | 4 | 4.35 | .302 | 1.27 | 8.9 | 2.6 | 8.9 | 124.0 | 122 | 61 | 60 | 13 | 36 | 123 | 0 | 13 | 5 | 0 | 0 | 3 | 1 | 3.32 |
| CL | Rivera, M.Rivera, Mariano | 39 | Destroyers | R | 96 | 84 | 0 | 9 | 5 | 3.32 | .260 | 1.03 | 7.5 | 1.8 | 9.0 | 100.1 | 83 | 39 | 37 | 15 | 20 | 100 | 0 | 30 | 6 | 0 | 0 | 3 | 2 | 3.64 |