| SP | Scherzer, M.Scherzer, Max | 34 | Lancers | R | 100 | 28 | 28 | 16 | 2 | 2.83 | .267 | 1.06 | 7.3 | 2.3 | 10.3 | 194.1 | 157 | 63 | 61 | 22 | 49 | 223 | 3 | 0 | 0 | 1 | 19 | 6 | 1 | 3.03 |
| SP | Buehler, W.Buehler, Walker | 23 | Highlanders | R | 97 | 28 | 28 | 11 | 9 | 3.54 | .303 | 1.28 | 8.5 | 3.1 | 9.4 | 175.1 | 165 | 69 | 69 | 22 | 60 | 182 | 0 | 0 | 0 | 0 | 16 | 4 | 3 | 3.65 |
| SP | deGrom, J.deGrom, Jacob # | 30 | Spiders | R | 99 | 28 | 28 | 14 | 4 | 3.73 | .291 | 1.19 | 8.3 | 2.4 | 10.7 | 178.2 | 165 | 74 | 74 | 22 | 48 | 212 | 1 | 0 | 0 | 0 | 19 | 7 | 2 | 3.15 |
| RP | Dominguez, S.Dominguez, Seranthony | 23 | Serpents | R | 96 | 86 | 0 | 17 | 3 | 2.61 | .311 | 1.31 | 6.2 | 5.7 | 9.2 | 117.1 | 80 | 34 | 34 | 11 | 74 | 120 | 0 | 6 | 4 | 0 | 0 | 5 | 16 | 4.20 |
| RP | Casilla, S.Casilla, Santiago | 38 | Serpents | R | 63 | 79 | 0 | 4 | 3 | 3.25 | .328 | 1.45 | 6.8 | 6.4 | 7.3 | 99.2 | 75 | 37 | 36 | 5 | 70 | 80 | 0 | 9 | 5 | 0 | 0 | 1 | 9 | 4.19 |
| RP | Doolittle, S.Doolittle, Sean | 31 | Pointers | L | 100 | 85 | 0 | 7 | 5 | 3.07 | .271 | 1.07 | 7.5 | 2.2 | 10.8 | 117.1 | 97 | 42 | 40 | 18 | 29 | 141 | 0 | 7 | 2 | 0 | 0 | 5 | 4 | 3.46 |