| SP | Scherzer, M.Scherzer, Max | 43 | Royals | R | 100 | 37 | 37 | 20 | 10 | 3.33 | .277 | 1.14 | 7.2 | 3.1 | 10.8 | 256.2 | 204 | 98 | 95 | 25 | 88 | 308 | 3 | 0 | 0 | 2 | 0 | 3 | 6 | 2.93 |
| SP | Thompson, J.Thompson, Jake | 29 | Indians | R | 97 | 37 | 37 | 15 | 15 | 3.66 | .276 | 1.13 | 7.2 | 3.0 | 8.1 | 275.2 | 219 | 117 | 112 | 26 | 93 | 246 | 12 | 0 | 0 | 1 | 0 | 4 | 11 | 3.50 |
| SP | Stinnett, J.Stinnett, Jake | 28 | Mariners | R | 90 | 38 | 38 | 20 | 11 | 3.56 | .277 | 1.14 | 7.7 | 2.5 | 6.6 | 270.1 | 232 | 111 | 107 | 40 | 75 | 199 | 16 | 0 | 0 | 4 | 0 | 3 | 0 | 4.32 |
| SP | Strasburg, S.Strasburg, Stephen | 38 | White Sox | R | 98 | 36 | 35 | 21 | 10 | 2.76 | .254 | 1.01 | 6.5 | 2.5 | 9.2 | 237.2 | 172 | 80 | 73 | 25 | 67 | 243 | 2 | 0 | 0 | 1 | 0 | 4 | 3 | 3.22 |
| RP | Ravenelle, A.Ravenelle, Adam | 31 | Royals | R | 95 | 87 | 0 | 8 | 7 | 2.03 | .262 | 1.03 | 6.9 | 2.5 | 8.0 | 168.1 | 128 | 42 | 38 | 14 | 46 | 150 | 0 | 20 | 7 | 0 | 0 | 5 | 6 | 3.21 |
| SU | Coulombe, D.Coulombe, Daniel | 30 | Red Sox | L | 86 | 95 | 0 | 10 | 4 | 3.60 | .285 | 1.17 | 7.0 | 3.5 | 11.2 | 142.1 | 111 | 60 | 57 | 16 | 55 | 177 | 0 | 4 | 4 | 0 | 0 | 4 | 5 | 3.22 |