| SP | Martinez, P.Martinez, Pedro | 29 | Patriots | R | 100 | 23 | 23 | 14 | 4 | 3.09 | .275 | 1.09 | 7.3 | 2.5 | 9.8 | 160.1 | 129 | 59 | 55 | 20 | 45 | 174 | 1 | 0 | 0 | 0 | 15 | 8 | 2 | 3.44 |
| SP | Halladay, R.Halladay, Roy | 28 | Bombers | R | 87 | 25 | 25 | 12 | 8 | 3.68 | .295 | 1.23 | 8.9 | 2.2 | 6.3 | 183.2 | 181 | 76 | 75 | 20 | 45 | 129 | 6 | 0 | 0 | 0 | 15 | 5 | 2 | 3.83 |
| SP | Mussina, M.Mussina, Mike # | 33 | Warriors | R | 67 | 24 | 24 | 15 | 5 | 4.93 | .313 | 1.32 | 9.6 | 2.4 | 8.1 | 157.0 | 167 | 89 | 86 | 26 | 41 | 142 | 1 | 0 | 0 | 0 | 12 | 7 | 5 | 4.26 |
| SP | Santana, J.Santana, Johan | 25 | Cats | L | 100 | 25 | 25 | 10 | 4 | 3.61 | .280 | 1.15 | 7.8 | 2.6 | 7.7 | 169.1 | 146 | 71 | 68 | 22 | 49 | 145 | 2 | 0 | 0 | 1 | 17 | 3 | 2 | 3.90 |
| RP | Rivera, M.Rivera, Mariano | 39 | Warriors | R | 96 | 63 | 0 | 8 | 0 | 2.63 | .250 | 0.97 | 6.8 | 2.0 | 9.1 | 96.0 | 72 | 29 | 28 | 6 | 21 | 97 | 0 | 6 | 2 | 0 | 0 | 3 | 1 | 2.54 |
| RP | Soriano, R.Soriano, Rafael | 24 | Reapers | R | 97 | 68 | 0 | 8 | 3 | 3.39 | .275 | 1.10 | 7.5 | 2.4 | 10.7 | 103.2 | 86 | 44 | 39 | 10 | 28 | 122 | 0 | 8 | 3 | 0 | 0 | 4 | 0 | 2.83 |
| CL | Papelbon, J.Papelbon, Jonathan | 26 | Patriots | R | 93 | 57 | 0 | 4 | 4 | 3.19 | .305 | 1.30 | 7.8 | 4.0 | 9.3 | 59.1 | 51 | 21 | 21 | 6 | 26 | 61 | 0 | 36 | 5 | 0 | 0 | 1 | 0 | 3.63 |