| SP | Martinez, P.Martinez, Pedro + | 0 | Red Sox | R | 100 | 33 | 33 | 16 | 9 | 3.16 | .267 | 1.07 | 6.9 | 2.7 | 9.0 | 227.2 | 175 | 87 | 80 | 12 | 69 | 226 | 7 | 0 | 0 | 2 | 18 | 5 | 4 | 2.67 |
| SP | McDowell, S.McDowell, Sam + | 0 | Indians | L | 76 | 32 | 32 | 18 | 8 | 2.64 | .267 | 1.06 | 5.8 | 3.8 | 8.1 | 241.2 | 155 | 76 | 71 | 15 | 102 | 216 | 6 | 0 | 0 | 3 | 23 | 7 | 3 | 3.37 |
| SP | Palmer, J.Palmer, Jim # + | 0 | Orioles | R | 76 | 33 | 33 | 15 | 12 | 3.29 | .258 | 1.02 | 6.7 | 2.5 | 5.1 | 241.0 | 179 | 92 | 88 | 23 | 66 | 136 | 9 | 0 | 0 | 2 | 25 | 7 | 3 | 4.02 |
| SP | Tanaka, M.Tanaka, Masahiro | 0 | Blue Jays | R | 68 | 30 | 30 | 12 | 11 | 4.25 | .302 | 1.29 | 8.5 | 3.1 | 8.8 | 182.0 | 172 | 89 | 86 | 26 | 62 | 178 | 1 | 0 | 0 | 0 | 20 | 2 | 7 | 3.96 |
| RP | Eckersley, D.Eckersley, Dennis + | 0 | Athletics | R | 91 | 83 | 0 | 8 | 2 | 2.21 | .248 | 0.97 | 6.9 | 1.8 | 8.0 | 151.0 | 116 | 46 | 37 | 11 | 30 | 134 | 0 | 19 | 3 | 0 | 0 | 3 | 3 | 2.83 |
| RP | Papelbon, J.Papelbon, Jonathan + | 0 | Red Sox | R | 98 | 99 | 0 | 6 | 5 | 3.03 | .266 | 1.06 | 7.0 | 2.5 | 9.5 | 145.1 | 113 | 53 | 49 | 8 | 41 | 153 | 0 | 13 | 2 | 0 | 0 | 4 | 5 | 2.54 |
| CL | Britton, Z.Britton, Zach + | 0 | Orioles | L | 93 | 63 | 0 | 9 | 4 | 1.47 | .198 | 0.73 | 4.2 | 2.4 | 8.2 | 79.2 | 37 | 14 | 13 | 4 | 21 | 72 | 0 | 37 | 5 | 0 | 0 | 1 | 3 | 2.67 |
| CL | Rivera, M.Rivera, Mariano + | 0 | Yankees | R | 94 | 63 | 0 | 7 | 9 | 3.58 | .271 | 1.08 | 7.0 | 2.8 | 8.6 | 75.1 | 58 | 32 | 30 | 9 | 23 | 72 | 0 | 35 | 6 | 0 | 0 | 3 | 1 | 3.68 |