| SP | Robertson, N.Robertson, Nate | 29 | Tigers | L | 78.0 | 17 | 17 | 9 | 2 | 2.72 | .291 | 1.20 | 7.8 | 3.0 | 6.1 | 116.0 | 100 | 35 | 35 | 7 | 39 | 78 | 1 | 0 | 0 | 1 | 12 | 4 | 3 | 3.55 |
| SP | Halladay, R.Halladay, Roy | 29 | Blue Jays | R | 76.0 | 18 | 18 | 9 | 3 | 3.43 | .296 | 1.24 | 9.1 | 2.2 | 7.0 | 133.2 | 134 | 54 | 51 | 13 | 32 | 103 | 6 | 0 | 0 | 1 | 12 | 3 | 3 | 3.51 |
| SP | McCarthy, B.McCarthy, Brandon | 23 | White Sox | R | 72.0 | 18 | 18 | 9 | 4 | 2.69 | .293 | 1.21 | 7.9 | 3.1 | 6.7 | 113.2 | 99 | 38 | 34 | 9 | 39 | 84 | 0 | 0 | 0 | 0 | 12 | 3 | 2 | 3.66 |
| SP | Santana, J.Santana, Johan # | 27 | Twins | L | 65.0 | 18 | 18 | 7 | 6 | 2.95 | .277 | 1.13 | 8.7 | 1.5 | 8.3 | 131.1 | 126 | 44 | 43 | 8 | 22 | 121 | 2 | 0 | 0 | 1 | 12 | 3 | 4 | 2.52 |
| SP | Contreras, J.Contreras, Jose | 35 | White Sox | R | 62.0 | 17 | 17 | 8 | 6 | 3.08 | .289 | 1.21 | 8.0 | 2.8 | 7.9 | 117.0 | 104 | 41 | 40 | 7 | 37 | 103 | 1 | 0 | 0 | 0 | 13 | 2 | 8 | 3.02 |