| SP | Martinez, P.Martinez, Pedro | 29 | Yard Birds | R | 100 | 34 | 34 | 15 | 11 | 3.94 | .294 | 1.19 | 8.4 | 2.3 | 10.2 | 226.0 | 211 | 107 | 99 | 29 | 57 | 257 | 8 | 0 | 0 | 2 | 20 | 14 | 3 | 3.34 |
| SP | Schmidt, J.Schmidt, Jason | 30 | Grasshoppers | R | 99 | 34 | 34 | 17 | 10 | 4.18 | .282 | 1.14 | 7.7 | 2.6 | 9.0 | 254.0 | 216 | 120 | 118 | 36 | 74 | 253 | 9 | 0 | 0 | 3 | 19 | 10 | 3 | 3.84 |
| SP | Duchscherer, J.Duchscherer, Justin | 31 | Ducks | R | 85 | 34 | 34 | 14 | 10 | 3.96 | .308 | 1.29 | 8.8 | 2.8 | 6.7 | 218.1 | 212 | 106 | 96 | 26 | 69 | 163 | 1 | 0 | 0 | 0 | 19 | 10 | 1 | 4.14 |
| SP | Hernandez, F.Hernandez, Felix | 19 | Reapers | R | 96 | 36 | 36 | 18 | 8 | 3.50 | .283 | 1.16 | 7.7 | 2.8 | 7.5 | 262.0 | 223 | 112 | 102 | 32 | 82 | 218 | 5 | 0 | 0 | 1 | 23 | 5 | 10 | 3.92 |
| SP | Johnson, R.Johnson, Randy | 38 | Ducks | L | 97 | 36 | 36 | 14 | 13 | 3.36 | .309 | 1.31 | 8.2 | 3.6 | 10.2 | 254.1 | 231 | 110 | 95 | 32 | 101 | 288 | 3 | 0 | 0 | 2 | 21 | 9 | 4 | 3.67 |
| RP | Papelbon, J.Papelbon, Jonathan | 26 | Red Bears | R | 93 | 88 | 0 | 12 | 3 | 3.09 | .280 | 1.12 | 6.9 | 3.2 | 9.1 | 137.0 | 105 | 48 | 47 | 13 | 49 | 139 | 0 | 2 | 7 | 0 | 0 | 6 | 0 | 3.41 |
| RP | Percival, T.Percival, Troy | 38 | Phils | R | 84 | 62 | 0 | 8 | 2 | 2.61 | .267 | 1.08 | 6.4 | 3.4 | 7.1 | 72.1 | 51 | 23 | 21 | 6 | 27 | 57 | 0 | 2 | 1 | 0 | 0 | 1 | 3 | 3.67 |
| CL | Rivera, M.Rivera, Mariano | 39 | Bashn' Bats | R | 96 | 79 | 0 | 6 | 9 | 3.24 | .267 | 1.05 | 7.7 | 1.8 | 8.4 | 91.2 | 78 | 35 | 33 | 14 | 18 | 85 | 0 | 35 | 3 | 0 | 0 | 4 | 1 | 3.86 |
| CL | Benitez, A.Benitez, Armando | 32 | Gators | R | 91 | 87 | 0 | 2 | 9 | 4.77 | .309 | 1.31 | 7.6 | 4.3 | 7.0 | 88.2 | 74 | 47 | 47 | 13 | 42 | 68 | 0 | 34 | 5 | 0 | 0 | 3 | 0 | 4.91 |