| SP | Halladay, R.Halladay, Roy | 28 | Blue Sox | R | 85 | 32 | 32 | 19 | 7 | 4.15 | .303 | 1.27 | 8.8 | 2.6 | 7.3 | 199.2 | 195 | 105 | 92 | 36 | 58 | 162 | 1 | 0 | 0 | 0 | 18 | 7 | 5 | 4.70 |
| SP | Martinez, P.Martinez, Pedro # | 29 | Mavericks | R | 100 | 33 | 33 | 9 | 18 | 3.79 | .294 | 1.21 | 8.2 | 2.7 | 9.0 | 263.2 | 240 | 115 | 111 | 32 | 78 | 264 | 14 | 0 | 0 | 1 | 16 | 11 | 0 | 3.59 |
| SP | Johnson, R.Johnson, Randy | 38 | Blue Sox | L | 97 | 33 | 33 | 12 | 8 | 3.57 | .287 | 1.18 | 7.2 | 3.5 | 11.0 | 216.2 | 173 | 87 | 86 | 25 | 83 | 263 | 5 | 0 | 0 | 2 | 20 | 6 | 5 | 3.31 |
| RP | Benitez, A.Benitez, Armando | 32 | Red Bears | R | 91 | 88 | 0 | 8 | 0 | 3.05 | .254 | 1.00 | 6.2 | 2.9 | 6.1 | 138.2 | 95 | 47 | 47 | 21 | 44 | 93 | 0 | 10 | 1 | 0 | 0 | 3 | 0 | 4.65 |
| RP | Balfour, G.Balfour, Grant | 31 | Dragons | R | 90 | 86 | 0 | 8 | 0 | 2.72 | .298 | 1.25 | 5.9 | 5.4 | 8.7 | 122.1 | 80 | 38 | 37 | 10 | 73 | 118 | 0 | 5 | 4 | 0 | 0 | 3 | 2 | 4.00 |
| CL | Soriano, R.Soriano, Rafael | 24 | Blues | R | 97 | 68 | 0 | 8 | 4 | 2.79 | .311 | 1.35 | 7.6 | 4.6 | 8.4 | 71.0 | 60 | 23 | 22 | 6 | 36 | 66 | 0 | 36 | 4 | 0 | 0 | 0 | 0 | 3.76 |
| CL | Papelbon, J.Papelbon, Jonathan | 26 | Jackals | R | 94 | 65 | 0 | 7 | 9 | 3.69 | .271 | 1.09 | 7.6 | 2.3 | 9.3 | 70.2 | 59 | 29 | 29 | 7 | 18 | 72 | 0 | 36 | 5 | 0 | 0 | 2 | 1 | 3.10 |