| SP | Jurrjens, J.Jurrjens, Jair | 28 | Braves | R | 148.0 | 35 | 35 | 19 | 12 | 3.35 | .304 | 1.29 | 8.5 | 3.1 | 6.9 | 263.1 | 249 | 106 | 98 | 18 | 90 | 202 | 9 | 0 | 0 | 4 | 20 | 6 | 1 | 3.45 |
| SP | Bailey, H.Bailey, Homer # | 28 | Reds | R | 134.0 | 34 | 34 | 20 | 7 | 3.95 | .291 | 1.21 | 8.7 | 2.2 | 8.4 | 239.1 | 232 | 114 | 105 | 26 | 58 | 222 | 3 | 0 | 0 | 0 | 18 | 5 | 6 | 3.35 |
| SP | Wainwright, A.Wainwright, Adam | 33 | Cardinals | R | 110.0 | 38 | 38 | 17 | 14 | 4.05 | .292 | 1.21 | 8.9 | 2.0 | 7.1 | 268.2 | 265 | 127 | 121 | 36 | 60 | 212 | 8 | 0 | 0 | 1 | 19 | 7 | 10 | 3.91 |
| SP | Lincecum, T.Lincecum, Tim | 30 | Giants | R | 106.0 | 33 | 33 | 13 | 14 | 3.71 | .290 | 1.20 | 7.8 | 3.0 | 10.1 | 242.2 | 209 | 103 | 100 | 21 | 82 | 271 | 10 | 0 | 0 | 3 | 22 | 7 | 8 | 2.99 |
| SP | Halladay, R.Halladay, Roy | 37 | Phillies | R | 103.0 | 33 | 33 | 14 | 17 | 3.63 | .281 | 1.15 | 8.4 | 2.0 | 7.3 | 247.2 | 231 | 108 | 100 | 24 | 54 | 201 | 11 | 0 | 0 | 3 | 19 | 5 | 2 | 3.35 |
| SP | Gonzalez, G.Gonzalez, Gio # | 29 | Phillies | L | 99.0 | 32 | 32 | 16 | 10 | 4.11 | .293 | 1.22 | 7.6 | 3.3 | 8.3 | 208.0 | 176 | 100 | 95 | 33 | 77 | 191 | 2 | 0 | 0 | 2 | 17 | 5 | 3 | 4.41 |
| SP | Cingrani, T.Cingrani, Tony | 24 | Reds | L | 97.0 | 34 | 34 | 11 | 7 | 2.65 | .287 | 1.18 | 7.2 | 3.5 | 8.8 | 169.2 | 135 | 52 | 50 | 13 | 66 | 166 | 0 | 0 | 0 | 0 | 4 | 4 | 2 | 3.28 |