| SP | Zambrano, C.Zambrano, Carlos # | 24 | Cubs | R | 91 | 22 | 22 | 13 | 4 | 3.87 | .268 | 1.06 | 6.3 | 3.2 | 7.6 | 151.1 | 106 | 69 | 65 | 21 | 54 | 128 | 3 | 0 | 0 | 1 | 13 | 6 | 4 | 4.30 |
| SP | Corbin, P.Corbin, Patrick | 31 | Nationals | L | 93 | 22 | 22 | 10 | 4 | 3.73 | .293 | 1.19 | 8.6 | 2.2 | 7.6 | 159.1 | 152 | 69 | 66 | 20 | 38 | 135 | 2 | 0 | 0 | 0 | 12 | 8 | 7 | 3.81 |
| SP | Wainwright, A.Wainwright, Adam | 34 | Brewers | R | 91 | 24 | 23 | 10 | 6 | 3.46 | .294 | 1.23 | 7.8 | 3.3 | 8.3 | 132.2 | 114 | 54 | 51 | 15 | 49 | 122 | 2 | 0 | 0 | 2 | 12 | 3 | 0 | 3.81 |
| SP | Scherzer, M.Scherzer, Max | 37 | Nationals | R | 93 | 22 | 22 | 11 | 7 | 3.56 | .296 | 1.24 | 7.3 | 3.9 | 10.9 | 134.0 | 108 | 54 | 53 | 14 | 58 | 163 | 0 | 0 | 0 | 0 | 13 | 3 | 0 | 3.29 |
| SP | Eickhoff, J.Eickhoff, Jerad | 34 | Phillies | R | 95 | 22 | 22 | 9 | 7 | 3.84 | .293 | 1.21 | 7.6 | 3.4 | 7.7 | 147.2 | 124 | 64 | 63 | 18 | 55 | 125 | 0 | 0 | 0 | 0 | 13 | 5 | 2 | 4.12 |
| RP | Frieri, E.Frieri, Ernesto | 33 | Padres | R | 99 | 62 | 0 | 5 | 2 | 2.33 | .287 | 1.16 | 6.4 | 4.0 | 12.8 | 81.0 | 58 | 31 | 21 | 8 | 36 | 115 | 0 | 7 | 0 | 0 | 0 | 4 | 2 | 2.93 |
| CL | Bastardo, A.Bastardo, Antonio | 32 | Phillies | L | 100 | 52 | 0 | 4 | 5 | 2.75 | .240 | 0.92 | 5.8 | 2.4 | 9.5 | 59.0 | 38 | 21 | 18 | 6 | 16 | 62 | 0 | 30 | 5 | 0 | 0 | 2 | 1 | 3.14 |
| CL | Papelbon, J.Papelbon, Jonathan | 29 | Nationals | R | 100 | 51 | 0 | 4 | 7 | 2.47 | .274 | 1.12 | 7.2 | 3.0 | 12.5 | 54.2 | 43 | 15 | 15 | 4 | 18 | 75 | 0 | 29 | 4 | 0 | 0 | 1 | 0 | 2.24 |