| SP | Hernandez, F.Hernandez, Felix | 19 | Grasshoppers | R | 58.0 | 13 | 13 | 7 | 3 | 3.16 | .283 | 1.16 | 7.8 | 2.7 | 7.5 | 99.2 | 86 | 38 | 35 | 13 | 30 | 82 | 3 | 0 | 0 | 0 | 7 | 2 | 1 | 4.02 |
| SP | Santana, J.Santana, Johan # | 25 | Warriors | L | 50.0 | 13 | 13 | 6 | 5 | 3.27 | .244 | 0.95 | 7.2 | 1.4 | 8.0 | 99.0 | 79 | 38 | 36 | 13 | 15 | 88 | 2 | 0 | 0 | 2 | 6 | 2 | 1 | 3.44 |
| SP | Martinez, P.Martinez, Pedro $$ | 29 | Mets | R | 48.0 | 13 | 13 | 6 | 6 | 3.94 | .273 | 1.08 | 8.0 | 1.7 | 10.5 | 105.0 | 93 | 50 | 46 | 16 | 20 | 123 | 8 | 0 | 0 | 0 | 7 | 5 | 1 | 3.35 |
| SP | Schmidt, J.Schmidt, Jason | 30 | Gators | R | 48.0 | 13 | 13 | 5 | 4 | 3.20 | .262 | 1.04 | 7.1 | 2.3 | 8.4 | 107.0 | 84 | 39 | 38 | 11 | 27 | 100 | 2 | 0 | 0 | 0 | 9 | 3 | 1 | 3.31 |
| SP | Vazquez, J.Vazquez, Javier | 33 | Mets | R | 40.0 | 13 | 13 | 6 | 3 | 3.96 | .305 | 1.32 | 9.3 | 2.7 | 7.9 | 88.2 | 91 | 40 | 39 | 10 | 26 | 77 | 1 | 0 | 0 | 0 | 7 | 0 | 3 | 3.61 |
| SP | Pettitte, A.Pettitte, Andy | 33 | Grizzlies | L | 39.0 | 13 | 13 | 8 | 4 | 4.81 | .337 | 1.46 | 10.2 | 3.1 | 7.1 | 76.2 | 86 | 43 | 41 | 17 | 26 | 60 | 1 | 0 | 0 | 0 | 6 | 5 | 0 | 5.55 |
| SP | Schilling, C.Schilling, Curt | 36 | Red Sox | R | 38.0 | 13 | 13 | 5 | 3 | 3.78 | .281 | 1.14 | 8.0 | 2.2 | 11.1 | 81.0 | 72 | 40 | 34 | 12 | 20 | 100 | 0 | 0 | 0 | 0 | 8 | 3 | 3 | 3.31 |