| SP | Vazquez, J.Vazquez, Javier | 33 | White Sox | R | 97 | 28 | 28 | 16 | 10 | 3.06 | .273 | 1.12 | 7.6 | 2.4 | 10.8 | 188.1 | 159 | 68 | 64 | 18 | 51 | 226 | 1 | 0 | 0 | 0 | 19 | 2 | 6 | 2.69 |
| SP | Hernandez, F.Hernandez, Felix | 23 | Mariners | R | 100 | 28 | 28 | 15 | 9 | 2.86 | .264 | 1.05 | 7.0 | 2.5 | 8.7 | 220.0 | 170 | 74 | 70 | 18 | 61 | 213 | 9 | 0 | 0 | 2 | 21 | 6 | 0 | 3.04 |
| SP | Halladay, R.Halladay, Roy | 32 | Blue Jays | R | 93 | 28 | 28 | 15 | 6 | 3.68 | .279 | 1.14 | 8.6 | 1.7 | 6.8 | 215.0 | 206 | 92 | 88 | 17 | 40 | 162 | 4 | 0 | 0 | 1 | 15 | 3 | 3 | 3.12 |
| CL | Percival, T.Percival, Troy | 40 | Angels | R | 94 | 64 | 0 | 5 | 3 | 2.77 | .267 | 1.09 | 6.1 | 3.7 | 6.9 | 65.0 | 44 | 20 | 20 | 7 | 27 | 50 | 0 | 28 | 1 | 0 | 0 | 0 | 3 | 4.11 |
| CL | Francisco, F.Francisco, Frank | 30 | Rangers | R | 87 | 58 | 0 | 4 | 4 | 3.29 | .273 | 1.13 | 6.4 | 3.7 | 9.3 | 63.0 | 45 | 23 | 23 | 6 | 26 | 65 | 0 | 35 | 4 | 0 | 0 | 0 | 4 | 3.41 |
| CL | Soriano, R.Soriano, Rafael | 30 | Mariners | R | 100 | 44 | 0 | 0 | 0 | 2.40 | .262 | 1.04 | 6.8 | 2.6 | 10.6 | 45.0 | 34 | 12 | 12 | 3 | 13 | 53 | 0 | 36 | 4 | 0 | 0 | 1 | 0 | 2.44 |
| CL | Carlson, J.Carlson, Jesse | 29 | Blue Jays | L | 93 | 56 | 0 | 5 | 8 | 2.75 | .304 | 1.20 | 6.5 | 4.4 | 6.5 | 55.2 | 40 | 21 | 17 | 2 | 27 | 40 | 0 | 35 | 4 | 0 | 0 | 6 | 0 | 3.82 |