| SP | Santana, J.Santana, Johan | 27 | Twins | L | 214.0 | 35 | 35 | 22 | 7 | 2.31 | .236 | 0.89 | 6.0 | 2.1 | 10.1 | 268.2 | 178 | 70 | 69 | 16 | 62 | 300 | 8 | 0 | 0 | 6 | 29 | 9 | 3 | 2.33 |
| SP | McKnight, T.McKnight, Tony | 29 | Colt 45s | R | 197.0 | 37 | 37 | 24 | 9 | 3.06 | .262 | 1.06 | 7.4 | 2.2 | 6.8 | 288.2 | 237 | 99 | 98 | 28 | 70 | 217 | 13 | 0 | 0 | 2 | 28 | 1 | 6 | 3.50 |
| SP | Rodriguez, R.Rodriguez, Ricardo # | 28 | Diamondbacks | R | 189.0 | 34 | 34 | 20 | 4 | 2.30 | .245 | 0.96 | 6.1 | 2.5 | 6.6 | 246.1 | 168 | 68 | 63 | 14 | 69 | 181 | 6 | 0 | 0 | 3 | 26 | 3 | 5 | 3.15 |
| SP | Waechter, D.Waechter, Doug | 25 | Rays | R | 156.0 | 33 | 33 | 16 | 9 | 2.31 | .252 | 0.95 | 6.2 | 2.4 | 9.2 | 238.0 | 163 | 63 | 61 | 14 | 64 | 243 | 2 | 0 | 0 | 1 | 27 | 14 | 0 | 2.71 |
| SP | Washburn, J.Washburn, Jarrod | 32 | Angels | L | 134.0 | 33 | 33 | 18 | 6 | 3.23 | .258 | 1.01 | 6.9 | 2.2 | 5.6 | 217.1 | 166 | 81 | 78 | 18 | 54 | 136 | 2 | 0 | 0 | 1 | 21 | 7 | 1 | 3.67 |
| SP | Hernandez, C.Hernandez, Carlos | 26 | Colt 45s | L | 133.0 | 32 | 32 | 19 | 7 | 3.13 | .266 | 1.04 | 6.6 | 2.7 | 6.3 | 201.0 | 148 | 81 | 70 | 29 | 61 | 140 | 0 | 0 | 0 | 0 | 21 | 10 | 5 | 4.54 |