| SP | Martinez, P.Martinez, Pedro | 29 | Wolves | R | 90.0 | 16 | 16 | 12 | 1 | 3.71 | .290 | 1.20 | 8.0 | 2.8 | 9.4 | 121.1 | 107 | 54 | 50 | 21 | 38 | 126 | 4 | 0 | 0 | 1 | 9 | 4 | 1 | 4.21 |
| SP | Halladay, R.Halladay, Roy | 28 | Demons | R | 77.0 | 16 | 16 | 10 | 4 | 3.32 | .274 | 1.11 | 8.0 | 2.1 | 7.2 | 124.2 | 110 | 48 | 46 | 15 | 29 | 99 | 4 | 0 | 0 | 1 | 10 | 2 | 3 | 3.73 |
| SP | Vazquez, J.Vazquez, Javier | 33 | Wolves | R | 69.0 | 15 | 15 | 11 | 4 | 3.48 | .292 | 1.23 | 8.3 | 2.7 | 9.0 | 93.0 | 86 | 39 | 36 | 8 | 28 | 93 | 0 | 0 | 0 | 0 | 11 | 1 | 3 | 3.05 |
| SP | Johnson, R.Johnson, Randy | 38 | Victory | L | 66.0 | 16 | 16 | 9 | 4 | 3.32 | .268 | 1.09 | 6.6 | 3.2 | 11.4 | 100.1 | 73 | 37 | 37 | 8 | 36 | 127 | 1 | 0 | 0 | 0 | 11 | 1 | 1 | 2.61 |
| SP | Clemens, R.Clemens, Roger # | 43 | Red Bears | R | 54.0 | 16 | 16 | 10 | 6 | 4.31 | .303 | 1.26 | 9.0 | 2.4 | 7.0 | 112.2 | 112 | 54 | 54 | 19 | 30 | 87 | 1 | 0 | 0 | 0 | 8 | 5 | 1 | 4.59 |
| SP | Greinke, Z.Greinke, Zack # | 26 | Wolves | R | 51.0 | 16 | 16 | 7 | 2 | 4.26 | .288 | 1.18 | 8.6 | 2.0 | 9.9 | 112.0 | 107 | 58 | 53 | 16 | 25 | 123 | 1 | 0 | 0 | 0 | 6 | 4 | 1 | 3.44 |
| SP | Pettitte, A.Pettitte, Andy | 33 | Units | L | 49.0 | 16 | 16 | 6 | 4 | 3.41 | .272 | 1.09 | 7.8 | 2.0 | 6.6 | 113.1 | 98 | 49 | 43 | 16 | 25 | 83 | 1 | 0 | 0 | 1 | 10 | 4 | 1 | 4.14 |